Comparison between three in vitro methods to measure magnesium degradation and their suitability for predicting in vivo degradation

The International Journal of Artificial Organs
Sara R Knigge, Birgit Glasmacher

Abstract

A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation. Two commonly used experimental protocols were examined: static conditions and a fluid changing method. For static testing, the samples stayed in fluid. For the fluid changing method, the fluid was changed after 2 and 5 days of immersion. In addition, a new method with continuous fluid flow was established. After an initial phase, the results confirm that for all three methods, the degradation behavior differs strongly. The static condition results in a very slow degradation rate. The fluid change method leads to a similar behavior like the static condition except that the degradation was speeded up after the fluid changes. The continuous degradation is linear for a long period after the initial phas...Continue Reading

References

May 8, 2003·Journal of Biomedical Materials Research. Part a·Ayako OyaneTakashi Nakamura
Aug 27, 2005·Biomaterials·Frank WitteHenning Windhagen
Oct 26, 2005·Biomaterials·Mark P StaigerGeorge Dias
Nov 13, 2008·Biomaterials·Xuenan GuTingfei Xi
Feb 15, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jemimah WalkerGeorge J Dias

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