Comparison between transmittance and reflectance measurements in glucose determination using near infrared spectroscopy

Journal of Biomedical Optics
Kye Jin JeonGilwon Yoon

Abstract

Glucose determination based on near-IR spectroscopy is investigated for reflectance and transmittance measurement. A wavelength range is 1100 to 2500 nm, which includes both the combination and overtone bands of glucose absorption. Intralipid solutions are used as samples, where glucose concentrations vary between 0 and 1000 mg/dl. Sample thickness for reflectance is 10 cm and 1- and 2-mm-thick samples are used for transmission. Partial least-squares regression (PLSR) analyses are performed to predict glucose concentrations. The standard errors of calibration are comparable between reflectance and 2-mm-thick transmittance. The reflectance method is inferior to the transmittance method in terms of the standard errors of prediction. Loading vector analysis for reflectance does not show glucose absorption features. Reflected light may not have enough information of glucose since a major portion of detected light has a short optical path length. In addition, prediction becomes more dependent on medium scattering rather than glucose, compared with transmission measurement. Loading vectors obtained from a PLSR transmittance analysis have glucose absorption profiles. The 1-mm-thick samples give better results than the 2-mm-thick sampl...Continue Reading

References

Jun 1, 1994·Artificial Organs·H M HeiseF A Gries
May 29, 2001·Journal of Biomedical Optics·T L Troy, S N Thennadil
Jul 27, 2001·Diabetes Technology & Therapeutics·J J BurmeisterG W Small
Oct 17, 2003·Nature·Paul Smaglik

❮ Previous
Next ❯

Citations

May 10, 2008·Journal of Biomedical Optics·Matti KinnunenSeppo Vainio
Sep 29, 2009·IEEE Transactions on Bio-medical Engineering·Sahba Talebi FardMarkus-Christian Amann
Oct 6, 2010·Journal of Diabetes Science and Technology·Natalia V Alexeeva, Mark A Arnold
Nov 6, 2009·Physics in Medicine and Biology·Xiang WenDan Zhu
Nov 18, 2014·Advanced Healthcare Materials·Nicholas M FarandosSeok Hyun Yun
May 24, 2018·Applied Optics·Etna YáñezS Juan Manuel Franco
Sep 6, 2011·Nanotechnology·Sounderya Nagarajan, Yong Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.