PMID: 2559Jan 15, 1976

Comparison between two antibody populations in the EBV system: anti-MA versus neutralizing antibody activity

International Journal of Cancer. Journal International Du Cancer
A de SchryverG Klein

Abstract

EBV-neutralizing antibody titers were determined in 11 sera derived from African Burkitt lymphoma or nasopharyngeal carcinoma patients and in the corresponding serum fractions retained above XM 100 Diaflo membranes after low pH treatment, and after recombination of the retained and passed fractions by neutralization of the acidified samples. They were compared with the corresponding antimembrane antigen (MA) titers in seven of the same sera. While all sera tested showed substantial increase of the anti-MA activity in the retained fraction, resulting in a significantly increased mean titer, EBV neutralizing activity did not change at all after identical treatment or changed only in a random fashion, resulting in stable mean titers. It is suggested that anti-MA and neutralizing antibodies are directed against at least partly different antigens on the virus.

References

Sep 15, 1971·International Journal of Cancer. Journal International Du Cancer·D SilvestreJ P Levy
Mar 1, 1966·Journal of Bacteriology·G Henle, W Henle
Jul 15, 1973·International Journal of Cancer. Journal International Du Cancer·P GunvénA Svedmyr
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P GunvénS Singh
Jun 1, 1973·Transactions of the New York Academy of Sciences
Jul 15, 1969·International Journal of Cancer. Journal International Du Cancer·G KleinL J Old
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Nov 1, 1971·The Biochemical Journal·T Ternynck, S Avrameas
Feb 1, 1964·Lancet·J V PULVERTAFT

Citations

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G J HoffmanS D Hayward
Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Oct 1, 1977·Australian and New Zealand Journal of Medicine·P Hersey

Related Concepts

Antibodies, Viral
African Burkitt's Lymphoma
Plasma Membrane
Epstein-Barr Virus
Hydrogen-Ion Concentration
Polyglobin
Cancer of Nasopharynx
Neutralization Tests

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