Comparison between two cord blood collection strategies

Acta Obstetricia Et Gynecologica Scandinavica
Pilar SolvesE Franco

Abstract

Collection strategy is the first step for collecting good quality cord blood (CB) units. There are two principal different techniques to collect CB from the umbilical vein: in the delivery room while the placenta is still in the uterus by midwives and obstetricians or in an adjacent room after placental delivery by CB-bank trained personnel. In this study, the benefits and disadvantages between two different CB collection strategies were evaluated in order to improve CB bank methodology. Valencia CB bank maintains the two different collection strategies aforementioned. Before processing CB units, volume was calculated and samples were drawn for cell counts. After processing and before cryopreservation, samples for cell counts, CD34 analysis, viability, clonogenic assays and microbiology were drawn directly from the bags. We compared the efficiency of the two collection techniques. Obstetric date and umbilical CB was obtained from 848 vaginal (484 collected in uterus and 364 collected ex uterus). The proportion of excluded CB units before processing was 33% for ex uterus and 25% for in uterus. The difference was statistically significant. A larger volume and a higher number of total nucleated cells, CD34+ cells and CFUs were har...Continue Reading

References

Aug 12, 1999·British Journal of Haematology·C DonaldsonJ Hows
Dec 20, 2000·American Journal of Obstetrics and Gynecology·D V SurbekW Holzgreve
Jul 18, 2001·Vox Sanguinis·S StanworthM Contreras
Mar 16, 2002·Transfusion·Rosemary L SparrowMark A Kirkland

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Citations

Nov 23, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mostafa JamaliMahin Nikougoftar Zarif
Oct 14, 2006·BMJ : British Medical Journal·Leroy C Edozien
Sep 8, 2011·Transfusion·Jonathan A GutmanGerald Zarlengo
May 14, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Lluís AmatJosep M Lailla
Jul 3, 2009·Vox Sanguinis·C M Khodabux, A Brand
Aug 22, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Erkan KalafatFeride Soylemez
Nov 23, 2010·JAAPA : Official Journal of the American Academy of Physician Assistants·Patsy Lynn SkablaJames Hampton
Apr 14, 2007·Transfusion Medicine·D SkoricP Rodic

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