Comparison between two-dimensional and three-dimensional quantitative coronary angiography for the prediction of functional severity in true bifurcation lesions: Insights from the randomized DK-CRUSH II, III, and IV trials

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Yao-Jun ZhangShao-Liang Chen

Abstract

This study investigated the diagnostic accuracy of three-dimensional quantitative coronary angiography (3D-QCA) compared with conventional 2D-QCA for predicting functional severity assessed by fractional flow reserve (FFR) for true bifurcation lesions. Based on pooled data from the randomized DK-CRUSH II, III, and IV trials, we evaluated the patients with true bifurcation lesions who underwent coronary angiography together with functional evaluations using FFR in both the main vessel and the side branch. Off-line 2D- and 3D-QCA analyses were conducted using dedicated bifurcation QCA analysis software. Measurements of minimum lumen diameter (MLD), percentage diameter stenosis (% DS), and minimum lumen area (MLA) were compared between 2D- and 3D-QCA, and we evaluated their predictive values of functionally significant FFR. Ninety patients were eligible for enrollment in the present study. In the main vessel, MLA measured by 3D-QCA was the most accurate predictor of FFR <0.75 (C statistic 0.85, P < 0.001), while MLD measured by 2D-QCA was a similarly accurate predictor (C statistic 0.85, P < 0.001). In the side branch, the best metrics for predicting FFR <0.75 were % DS measured by 2D-QCA with a C statistic value of 0.91 (P < 0.00...Continue Reading

References

Jan 1, 1991·Clinical Cardiology·D Katritsis, M Webb-Peploe
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Mar 1, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Steve RamcharitarPatrick W Serruys
Jun 26, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giovanna SarnoPatrick W Serruys
Oct 12, 2010·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Danny DvirRan Kornowski
Mar 22, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Pierfrancesco AgostoniPieter R Stella
Mar 22, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Chrysafios GirasisPatrick W Serruys
Aug 29, 2012·The New England Journal of Medicine·William E Boden
Mar 30, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael MagroRobert-Jan van Geuns
May 18, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Chrysafios GirasisPatrick W Serruys
Jul 26, 2014·JACC. Cardiovascular Interventions·Alexandra J Lansky, Cody Pietras
Mar 6, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Makoto NatsumedaYuji Ikari
Apr 29, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Takashi MuramatsuUNKNOWN TRYTON Pivotal IDE Coronary Bifurcation Trial Investigators

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Citations

Aug 23, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dobrin VassilevPatrick W Serruys

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