PMID: 6270980Jan 1, 1981

Comparison between two radiation protective substances in irradiated mice. Effect on splenic haemopoiesis

Acta Radiologica. Oncology
J C CarfagniniC Rönnbäck

Abstract

The radiation protective action of 2,2'-Dithiobis(N-[(1-adamantyl)-methyl]-acetamidine)-dihyrochloride (S-75) and cysteamine was compared in splenectomized and non-splenectomized mice. Cysteamine was found to have better and more general protection properties. Several indications of a specific effect of S-75 on the spleen were observed. It is suggested that the protection properties of S-75 should be tested in another laboratory animal not having such a marked splenic haemopoiesis as the mouse.

References

Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·L OusavaplangchaiA Nilsson
Dec 1, 1972·Journal of Medicinal Chemistry·R D WestlandM M Grenan
Jun 1, 1969·Life Sciences·D R BoggsP A Chervenick
Apr 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·L O JACOBSON, E K MARKS

Citations

May 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·O Vos, W S Roos-Verhey

Related Concepts

2,2-dithiobis(N-(1-adamantyl)methyl)acetamide dihydrochloride, hemihydrate
Acetamides
Adamantane
Hematopoiesis, Medullary
Hemorrhage
Mice, Inbred CBA
Radiation-Protective Effect
Spleen
Splenectomy
Thioacetamide

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