PMID: 8473635May 1, 1993

Comparison in women versus men of composition of atherosclerotic plaques in native coronary arteries and in saphenous veins used as aortocoronary conduits

Journal of the American College of Cardiology
S L MautnerW C Roberts


This study quantifies and compares the components of atherosclerotic plaques in native coronary arteries and in saphenous vein grafts used for aortocoronary bypass surgery in women versus those in men. Plaque composition has been described in various manifestations of fatal coronary artery disease and after the bypass operation, but no reports have investigated this composition according to gender. A total of 979 5-mm segments of native coronary arteries and 842 5-mm segments of saphenous vein grafts were examined by computerized planimetric technique in 11 women and 11 men who were matched for survival time after the bypass operation. Comparison of the plaque components revealed that atherosclerotic plaques in women, compared with those in men, contained significantly more cellular fibrous tissue, both in native coronary arteries (mean 38% vs. 4%, p < 0.001) and in saphenous vein grafts (mean 70% vs. 36%, p < 0.05). In contrast, the proportion of dense fibrous tissue was significantly less in the atherosclerotic plaques of women than in those of men, both in native coronary arteries (mean 50% vs. 85%, p < 0.001) and in saphenous vein grafts (mean 25% vs. 57%, p < 0.05). Cellular fibrous tissue is often found at an early stage ...Continue Reading


Jan 1, 1976·Cleveland Clinic Quarterly·L R Golding, L K Groves
May 1, 1978·The Annals of Thoracic Surgery·D H TyrasV L Willman
Sep 1, 1985·Chest·J B AtkinsonR Virmani
Sep 14, 1974·Lancet·J J BarboriakM E Korns
Oct 1, 1971·Circulation·Z Vlodaver, J E Edwards
Feb 1, 1983·Journal of the American College of Cardiology·F D LoopW C Sheldon
Nov 1, 1982·The Annals of Thoracic Surgery·D A KillenH H Bell


May 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·S R UnderwoodRoyal College of Radiologists
Aug 7, 2013·Journal of Cardiovascular Translational Research·Vivian G NgAlexandra J Lansky
Dec 13, 2000·The American Journal of Cardiology·F AlfonsoC Macaya
Jun 12, 2003·Journal of the American College of Cardiology·Allen P BurkeJames E Muller
Feb 24, 2001·Coronary Artery Disease·S E SheiferN J Weissman
Dec 21, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan Ruiz-GarcíaGregg W Stone
Apr 22, 2014·Journal of Diabetes and Its Complications·Yoko IrieIichiro Shimomura
Apr 10, 2013·Journal of Pharmaceutical Sciences·Ji GuoDinesh V Patwardhan
Nov 17, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fabio TavoraAllen P Burke
Sep 1, 1995·American Heart Journal·W C Roberts
Dec 10, 2008·The American Journal of Cardiology·Vincent E FriedewaldJ T Willerson
Nov 1, 2005·Journal of the American College of Cardiology·Vera Bittner
Mar 23, 2017·International Heart Journal·Lu YihuaZhao Dongshen
Apr 3, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D J BrazP L da Luz
Feb 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D H Blankenhorn, H N Hodis
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·O JoakimsenB K Jacobsen
Jul 20, 2007·Proceedings·William C Roberts, W Bruce Fye
Mar 12, 2021·The International Journal of Cardiovascular Imaging·Mohammed El MahdiuiArthur J Scholte

Related Concepts

Tumoral Calcinosis
Coronary Artery Disease
Sinus Node Artery
Foam Cells
Lymphoid Cells
Saphenous Vein

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.