Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.

NeuroImage
William C KreislRobert B Innis

Abstract

Ten percent of humans lack specific binding of [(11)C]PBR28 to 18 kDa translocator protein (TSPO), a biomarker for inflammation. "Non-binders" have not been reported using another TSPO radioligand, [(11)C]-(R)-PK 11195, despite its use for more than two decades. This study asked two questions: (1) What is the cause of non-binding to PBR28? and (2) Why has this phenomenon not been reported using [(11)C]-(R)-PK 11195? Five binders and five non-binders received whole-body imaging with both [(11)C]-(R)-PK 11195 and [(11)C]PBR28. In vitro binding was performed using leukocyte membranes from binders and non-binders and the tritiated versions of the ligand. Rhesus monkeys were imaged with [(11)C]-(R)-PK 11195 at baseline and after blockade of TSPOs. Using [(11)C]PBR28, uptake in all five organs with high densities of TSPO (lung, heart, brain, kidney, and spleen) was 50% to 75% lower in non-binders than in binders. In contrast, [(11)C]-(R)-PK 11195 distinguished binders and non-binders in only heart and lung. For the in vitro assay, [(3)H]PBR28 had more than 10-fold lower affinity to TSPO in non-binders than in binders. The in vivo specific binding of [(11)C]-(R)-PK 11195 in monkey brain was approximately 80-fold lower than that report...Continue Reading

References

Nov 12, 1984·Life Sciences·P MoingeonC Bohuon
Oct 5, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Keqiang ZhangThierry Hauet
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Annachiara CagninRichard B Banati
Nov 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amira K BrownRobert B Innis
Dec 20, 2007·Molecular Cancer Therapeutics·Curtis J HenrichJames B McMahon

❮ Previous
Next ❯

Citations

Jul 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Akihiro TakanoChrister Halldin
Sep 28, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Unsong OhSteven Jacobson
Sep 8, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Erin HarbertsSteven Jacobson
Nov 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·C LinnmanD Borsook
May 13, 2011·Epilepsia·Eleonora Aronica, Peter B Crino
Jan 10, 2013·PloS One·Philippe CorciaMaria-Joao Ribeiro
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David R J OwenChristine A Parker
Jan 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jussi HirvonenWilliam H Theodore
Jan 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher J EndresMartin G Pomper
Nov 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christina S HinesRobert B Innis
Sep 12, 2013·Future Cardiology·William S A JenkinsMarc R Dweck
Jun 19, 2013·Brain : a Journal of Neurology·William C KreislUNKNOWN Biomarkers Consortium PET Radioligand Project Team
Oct 13, 2015·British Journal of Pharmacology·L E LaskarisC Pantelis
Jul 7, 2012·Current Opinion in Neurology·Joseph C MasdeuKaren F Berman
Nov 18, 2015·Muscle & Nerve·Michael BenatarLucie Bruijn
Dec 17, 2011·Nuclear Medicine and Biology·Nicolas ArlicotDenis Guilloteau
Jul 12, 2011·Bioorganic & Medicinal Chemistry Letters·Annelaure DamontFrédéric Dollé
Dec 20, 2015·Journal of Huntington's Disease·Andreas-Antonios Roussakis, Paola Piccini
Oct 28, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Arpna SrivastavaP Sarat Chandra
Nov 4, 2015·Neurochemistry International·Madhuri VenigallaGerald Münch
Aug 4, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paolo Zanotti-FregonaraRobert B Innis
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenJustin P Rubio
Sep 13, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William C KreislUNKNOWN Biomarkers Consortium PET Radioligand Project Team
Aug 22, 2015·European Journal of Nuclear Medicine and Molecular Imaging·K CollsteS Cervenka
Apr 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenChristine A Parker
Jul 10, 2014·EJNMMI Research·Maria-Joao RibeiroDenis Guilloteau
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Grazia D Femminella, Paul Edison
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James VarleyPaul Edison
May 23, 2012·Glia·Sriram VennetiClayton A Wiley
Mar 16, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hui LiuZhude Tu
Apr 26, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Vincent Médran-NavarreteFrédéric Dollé
Jul 4, 2015·Brain : a Journal of Neurology·Aurelija JucaiteLars Farde
Sep 10, 2014·Neuroscience·H AmhaoulS Dedeurwaerdere
Dec 3, 2014·Brain Research·Christopher J McDougleWilliam A Carlezon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
David R OwenChristine A Parker
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
David R OwenChristine A Parker
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
David R OwenJustin P Rubio
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Amira K BrownRobert B Innis
© 2022 Meta ULC. All rights reserved