PMID: 8454481Mar 15, 1993Paper

Comparison of 131I- and 90Y-labeled monoclonal antibody 17-1A for treatment of human colon cancer xenografts

International Journal of Radiation Oncology, Biology, Physics
D BuchsbaumZ Steplewski

Abstract

The choice of radionuclide remains an important question in clinical radioimmunotherapy. Therefore, a study was initiated, using an in vivo model system, to assess the relative merits of 131I- and 90Y-labeled 17-1A monoclonal antibody as therapeutic agents in the treatment of colon cancer. 131Iodine- and 90Y-labeled 17-1A were assessed in animal therapy trials using athymic nude mice bearing LS174T human colon cancer xenografts. 131Iodine-labeled 17-1A decreased tumor growth in a dose-dependent fashion without lethality. In contrast, the doses of 90Y-labeled 17-1A which were required to produce a significant increase in tumor doubling time also caused marked toxicity. Although similar tumor growth inhibition was produced by 250 microCi 90Y- and 150 microCi 131I-labeled 17-1A, Medical Internal Radiation Dose calculations based on biodistribution data estimated that the dose delivered by 90Y was greater than that delivered by 131I. To investigate this discrepancy, 3-dimensional dose distributions within LS174T tumors were assessed using autoradiography and 3-dimensional calculational techniques. It was found that a greater fraction of the dose was deposited in the tumor after treatment with 131I- compared to 90Y-labeled 17-1A. Wh...Continue Reading

References

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Citations

Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·R M SharkeyD M Goldenberg
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·R MayerJ R Williams
Sep 30, 1988·Biochemical and Biophysical Research Communications·J EscribanoE Méndez
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Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C BuskeW Hiddemann
Jun 22, 2001·Critical Reviews in Oncology/hematology·G L DeNardoS J DeNardo
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M ConnettM J Welch

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