Comparison of 18 F-FDG PET/MRI and MRI for pre-therapeutic tumor staging of patients with primary cancer of the uterine cervix

European Journal of Nuclear Medicine and Molecular Imaging
Theresia SarabhaiJohannes Grueneisen

Abstract

The aim of the present study was to assess and compare the diagnostic performance of integrated PET/MRI and MRI alone for local tumor evaluation and whole-body tumor staging of primary cervical cancers. In addition, the corresponding impact on further patient management of the two imaging modalities was assessed. A total of 53 consecutive patients with histopathological verification of a primary cervical cancer were prospectively enrolled for a whole-body 18F-FDG PET/MRI examination. Two experienced physicians analyzed the MRI data, in consensus, followed by a second reading session of the PET/MRI datasets. The readers were asked to perform a dedicated TNM staging in accordance with the 7th edition of the AJCC staging manual. Subsequently, the results of MRI and PET/MRI were discussed in a simulated interdisciplinary tumor board and therapeutic decisions based on both imaging modalities were recorded. Results from histopathology and cross-sectional imaging follow-up served as the reference standard. PET/MRI allowed for a correct determination of the T stage in 45/53 (85%) cases, while MRI alone enabled a correct identification of the tumor stage in 46/53 (87%) cases. In 24 of the 53 patients, lymph node metastases were present....Continue Reading

References

Jul 1, 1993·Journal of Computer Assisted Tomography·C K HohE Nitzsche
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Tom R Miller, Perry W Grigsby
Mar 26, 2005·Gynecologic Oncology·Laura J HavrileskyEvan R Myers
May 23, 2007·AJR. American Journal of Roentgenology·Evis SalaDavid Lomas
Oct 19, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Yoshihiro NishiyamaMotoomi Ohkawa
Nov 22, 2007·JAMA : the Journal of the American Medical Association·Julie K SchwarzPerry W Grigsby
Mar 26, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tara J SelmanKhalid Khan
Mar 17, 2009·Journal of Cancer Research and Clinical Oncology·Matthias W BeckmannUNKNOWN Uterus Commission of the Gynecological Oncology Working Group (AGO)
Apr 4, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio PecorelliFranco Odicino
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Julie K SchwarzDominique Delbeke
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Nov 9, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Helen C AddleyEvis Sala
Sep 10, 2013·European Journal of Radiology·Karsten BeiderwellenThomas C Lauenstein
Jun 24, 2014·Women's Health·Maura MiccòHebert Alberto Vargas
Aug 13, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Philipp HeuschChristian Buchbender
Nov 2, 2014·Seminars in Nuclear Medicine·Paul GrantHeather A Jacene
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 29, 2015·European Radiology·Marcelo A QueirozPatrick Veit-Haibach
Jul 23, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Johannes GrueneisenLale Umutlu

❮ Previous
Next ❯

Citations

Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Judit A AdamBerthe L van Eck-Smit
Aug 28, 2019·Journal of Computer Assisted Tomography·Mayur VirarkarPriya R Bhosale
Feb 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Meiling XiaoJinwei Qiang
Jul 31, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Johanna MerzMichel Eisenblaetter
Oct 3, 2020·EJNMMI Research·Hideaki TsuyoshiYoshio Yoshida
Jul 9, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria SalvoPedro T Ramirez
Jul 31, 2019·Current Oncology Reports·Ingfrid S HaldorsenHenrica M J Werner
Aug 17, 2020·Journal of Magnetic Resonance Imaging : JMRI·I-Lun ShihTiffany Ting-Fang Shih
Jan 24, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Aida SteinerJohanna Virtanen
Jan 9, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Felipe S FurtadoOnofrio A Catalano
Oct 24, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hideaki TsuyoshiYoshio Yoshida
Jan 29, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Chen XuHongzan Sun
Feb 9, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tyler J FraumRichard L Wahl
Jan 30, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias WeissingerHelmut Dittmann
Aug 14, 2021·The British Journal of Radiology·Lisa A MinDoenja M J Lambregts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.