Comparison of 18 F-GE-180 and dynamic 18 F-FET PET in high grade glioma: a double-tracer pilot study

European Journal of Nuclear Medicine and Molecular Imaging
Marcus UnterrainerNathalie L Albert

Abstract

PET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as 18F-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. 18F-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually compared its uptake characteristics to dynamic 18F-FET PET and contrast-enhanced MRI in patients with HGG. Twenty HGG patients (nine IDH-wildtype, 11 IDH-mutant) at initial diagnosis (n = 8) or recurrence (n = 12) were consecutively included and underwent 18F-GE-180 PET, dynamic 18F-FET PET, and MRI. The maximal tumour-to-background ratios (TBRmax) and biological tumour volumes (BTV) were evaluated in 18F-GE-180 and 18F-FET PET. Dynamic 18F-FET PET analysis included the evaluation of minimal time-to-peak (TTPmin). In MRI, the volume of contrast-enhancement was delineated (VOLCE). Volumes were spatially correlated using the Sørensen-Dice coefficient. The median TBRmax tended to be higher in 18F-GE-180 PET compared to 18F-FET PET [4.58 (2.33-8.95) vs 3.89 (1.56-7.15); p = 0.062] in the overall group. In subgroup analyses, IDH-wildtype gliomas showed a s...Continue Reading

References

Jan 1, 1992·Neuroradiology·M WatanabeN Takeda
Dec 1, 1989·Annals of Neurology·L JunckS Starosta-Rubinstein
Feb 4, 2005·Brain : a Journal of Neurology·Dirk PauleitKarl-Josef Langen
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David R J OwenChristine A Parker
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenJustin P Rubio
Jan 17, 2012·Bioorganic & Medicinal Chemistry Letters·Harry WadsworthWilliam Trigg
Jan 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Alexandra WinkelerBertrand Tavitian
Apr 12, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Nathalie L JansenChristian la Fougère
Nov 12, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali R AwdeAlexandra Winkeler
Jan 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nathalie L JansenChristian la Fougère
Jan 23, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Torild WickstrømWilliam Trigg
Feb 12, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alex M DickensLaura Airas
May 23, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Dewei TangH Charles Manning
Oct 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Hervé BoutinWilliam Trigg
Dec 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nathalie L JansenChristian la Fougère
Jan 23, 2015·Neurology·Bogdana SuchorskaUNKNOWN German Glioma Network
Feb 28, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhangjie SuKarl Herholz
Jul 18, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Per JensenLars H Pinborg
Apr 2, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marcus UnterrainerNathalie L Albert
Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhen FanPaul Edison
Jun 29, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Claire FeeneyDavid J Sharp
Aug 3, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sujata SridharanHervé Boutin
Jul 15, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias BrendelAxel Rominger
Aug 20, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Nathalie L AlbertM Niyazi
Oct 19, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Antoine VergerNorbert Galldiks
Mar 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·M UnterrainerN L Albert
Mar 11, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Marcus UnterrainerNathalie L Albert
Jun 13, 2018·Data in Brief·Maximilian DeussingMatthias Brendel

❮ Previous
Next ❯

Citations

Jan 19, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraJoseph C Masdeu
Feb 9, 2020·International Journal of Molecular Sciences·Ilanah J PruisSophie E M Veldhuijzen van Zanten
Mar 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan-Michael WernerNorbert Galldiks
Sep 6, 2019·European Journal of Nuclear Medicine and Molecular Imaging·M UnterrainerN L Albert
Mar 4, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Nathalie L AlbertPeter Bartenstein
Feb 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraFederico Turkheimer
Jan 23, 2020·International Journal of Molecular Sciences·Linzhi CaiRoland E Kälin
Oct 18, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Philipp LohmannNorbert Galldiks
Jun 12, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Nathalie L AlbertP Bartenstein
Oct 17, 2020·Clinical Nuclear Medicine·Franziska J VettermannNathalie L Albert
Dec 10, 2020·Diagnostics·Csaba Juhász, Sandeep Mittal
Feb 17, 2021·PET Clinics·Austin J BorjaAbass Alavi
Mar 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Bastian ZinnhardtAlexandra Winkeler
Jun 25, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gurvan DissauxUlrike Schick
Dec 24, 2020·European Biophysics Journal : EBJ·Gwladys RivièreMarkus Zweckstetter
Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauHervé Boutin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.