Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009-2014)

Journal of the American Veterinary Medical Association
Damiano StefanelloLaura Marconato

Abstract

To compare the Kiupel (2 categories) and Patnaik (3 categories) histologic grading systems for predicting the presence of metastasis at the time of initial examination in dogs with cutaneous mast cell tumors (MCTs). Retrospective case series. 386 client-owned dogs with cutaneous MCTs. Medical records of dogs with newly diagnosed, histologically confirmed cutaneous MCTs that had undergone complete clinical staging were reviewed for clinical and histopathologic data. All Patnaik grade 1 MCTs (n = 52) were classified as Kiupel low-grade MCTs, and all Patnaik grade 3 MCTs (43) were classified as Kiupel high-grade MCTs. Of the 291 Patnaik grade 2 MCTs, 243 (83.5%) were classified as Kiupel low-grade tumors, and 48 (16.5%) were classified as Kiupel high-grade MCTs. Dogs with Patnaik grade 3 MCTs were significantly more likely to have metastases at the time of initial examination than were dogs with grade 1 or 2 MCTs (OR, 5.46), and dogs with Kiupel high-grade MCTs were significantly more likely to have metastases than were dogs with Kiupel low-grade MCTs (OR, 2.54). However, 3 of 52 (5.8%) dogs with Patnaik grade 1 tumors, 48 of 291 (16.5%) dogs with Patnaik grade 2 tumors, and 44 of 295 (14.9%) dogs with Kiupel low-grade tumors had ...Continue Reading

Citations

Aug 3, 2016·Veterinary Clinical Pathology·Franziska HergtJohannes Hirschberger
Dec 30, 2015·Veterinary Pathology·D J MeutenJ W George
Jan 28, 2017·Veterinary Pathology·C H C HalseyE J Ehrhart
Jun 8, 2018·Veterinary Medicine and Science·Jennifer K ReaganLaura D Garrett
Jul 27, 2018·Veterinary and Comparative Oncology·Laura MarconatoSilvia Sabattini
Aug 24, 2018·Veterinary and Comparative Oncology·Michael WillmannPeter Valent
Sep 25, 2018·Veterinary Pathology·Silvia Sabattini, Giuliano Bettini
Jan 30, 2019·Veterinary Dermatology·Jessika DanielRicardo F Strefezzi
Jan 7, 2017·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hiroyuki MochizukiMatthew Breen
Jul 2, 2019·The Journal of Veterinary Medical Science·Mun Keong KokHiroyuki Nakayama
Feb 20, 2018·Veterinary Pathology·Don MeutenMarlene Hauck
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Michelle L Campbell-WardCheryl Sangster
Mar 27, 2021·Veterinary Pathology·Giancarlo AvallonePaola Roccabianca
Jul 21, 2021·Veterinary Pathology·Donald J MeutenDerick Whitley
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Roberta FerrariDamiano Stefanello
Sep 27, 2021·Veterinary and Comparative Oncology·Csilla FejösJohannes Hirschberger

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