Comparison of 2D and 3D imaging and treatment planning for postoperative vaginal apex high-dose rate brachytherapy for endometrial cancer

International Journal of Radiation Oncology, Biology, Physics
James K RussoSusan Richardson

Abstract

To evaluate bladder and rectal doses using two-dimensional (2D) and 3D treatment planning for vaginal cuff high-dose rate (HDR) in endometrial cancer. Ninety-one consecutive patients treated between 2000 and 2007 were evaluated. Seventy-one and 20 patients underwent 2D and 3D planning, respectively. Each patient received six fractions prescribed at 0.5 cm to the superior 3 cm of the vagina. International Commission on Radiation Units and Measurements (ICRU) doses were calculated for 2D patients. Maximum and 2-cc doses were calculated for 3D patients. Organ doses were normalized to prescription dose. Bladder maximum doses were 178% of ICRU doses (p < 0.0001). Two-cubic centimeter doses were no different than ICRU doses (p = 0.22). Two-cubic centimeter doses were 59% of maximum doses (p < 0.0001). Rectal maximum doses were 137% of ICRU doses (p < 0.0001). Two-cubic centimeter doses were 87% of ICRU doses (p < 0.0001). Two-cubic centimeter doses were 64% of maximum doses (p < 0.0001). Using the first 1, 2, 3, 4 or 5 fractions, we predicted the final bladder dose to within 10% for 44%, 59%, 83%, 82%, and 89% of patients by using the ICRU dose, and for 45%, 55%, 80%, 85%, and 85% of patients by using the maximum dose, and for 37%, 6...Continue Reading

References

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Citations

Aug 27, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E Jouglar, I Barillot
Jul 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Angeles RovirosaAlbert Biete
Apr 23, 2015·Brachytherapy·Sebastia SabaterJesus Fernandez-Lopez
Dec 11, 2014·Journal of Applied Clinical Medical Physics·Winson ZhangYusung Kim

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