Comparison of 3T and 7T ASL techniques for concurrent functional perfusion and BOLD studies

NeuroImage
Dimo IvanovKâmil Uludağ

Abstract

Arterial spin labeling (ASL) is the primary non-invasive MRI approach to measure baseline cerebral blood flow (CBF) in healthy subjects and patients. ASL also allows concurrent functional BOLD signal and CBF measurements, but the latter typically suffer from low contrast-to-noise (CNR) ratio. Ultra-high-field imaging significantly boosts BOLD signal CNR. However, it is contested whether also CBF CNR benefits from increasing magnetic field strength, especially given that technical challenges related to field inhomogeneities and power deposition constraints exist. Recently, we presented an optimized PASL technique that utilizes tr-FOCI inversion pulses and dielectric pads to overcome the temporal resolution limitations of previous 7T ASL implementations (Ivanov et al., in press; 2017). The primary goal of this study was to compare its performance to that of 3T ASL approaches - both pulsed ASL (PASL) and pseudo-continuous (pCASL) - concerning functional studies using simultaneous CBF and BOLD signal acquisition. To this aim, we investigated a wide range of parameters that can influence CBF and BOLD signal sensitivities: spatial resolution, labeling scheme, parallel imaging and echo time. We found that 7T ASL is superior in terms o...Continue Reading

Citations

Jun 4, 2019·International Journal of Molecular Sciences·Lorenzo Carnevale, Giuseppe Lembo
Sep 5, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hacene SerraiRavi S Menon
Mar 27, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maria EngelKlaas P Pruessmann
Dec 22, 2019·Scientific Reports·Gilad Liberman, Benedikt A Poser
Nov 20, 2019·NeuroImage·Yuhui ChaiPeter A Bandettini
Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Jiajia YangPeter A Bandettini
Sep 4, 2021·NeuroImage·Luisa RaimondoWietske van der Zwaag
Nov 16, 2021·NeuroImage·Xingfeng ShaoDanny J J Wang
Nov 25, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Linqing LiPeter Bandettini
Nov 2, 2020·Progress in Neurobiology·Saskia Bollmann, Markus Barth

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