Comparison of 4 mg versus 20 mg intravitreal triamcinolone acetonide injections.

The British Journal of Ophthalmology
A M TammewarWilliam R Freeman

Abstract

To compare the non-decanted (standard) 4 mg versus the decanted 20 mg intravitreal triamcinolone acetonide (IVTA) injections and to assess their effect on intraocular pressure (IOP). We retrospectively reviewed the records of 92 consecutive eyes, which received an intravitreal injection of either dose of triamcinolone acetonide, at a single retina centre. The change in IOP (elevation of at least 5 mm Hg from baseline or above 21 mm Hg) was analysed with a multivariate logistic analysis. The mean follow-up period in both groups was 27 weeks. A subgroup analysis comparing vitrectomised to non-vitrectomised eyes in both groups was also performed. Of the 92 eyes, 46% (23 of 51) in the 4 mg group versus 30% (12 of 41) in the 20 mg group had an IOP >21 mm of Hg (p = 0.14) after a mean follow-up period of 27 weeks. The vitrectomised eyes (3 of 24) in the 20 mg group had a significantly lower rate of IVTA induced IOP elevation than the non-vitrectomised eyes (9 of 17) (p = 0.013). The IOP elevation occurred significantly earlier in the 4 mg group (vitrectomised eyes 27 (SD 43) days and non-vitrectomised eyes 61 (52) days) than in the 20 mg group (vitrectomised eyes 104 (56) days and non-vitrectomised eyes 119 (82) days), independent of...Continue Reading

References

Jan 21, 2000·Australian and New Zealand Journal of Ophthalmology·R J Wingate, P E Beaumont
May 3, 2002·Ophthalmology·Adam MartidisCaroline Baumal
Dec 19, 2002·The British Journal of Ophthalmology·J B JonasR Degenring
Jan 14, 2003·Archives of Ophthalmology·Jost B JonasRobert F Degenring
May 14, 2003·Archives of Ophthalmology·Jost B JonasRobert Degenring
Jul 31, 2003·American Journal of Ophthalmology·Jost B JonasRobert F Degenring
Feb 11, 2004·Archives of Ophthalmology·Jost B JonasRobert F Degenring
Mar 10, 2004·Archives of Ophthalmology·Mark C GilliesAlex B L Hunyor
Mar 12, 2004·American Journal of Ophthalmology·Jost B Jonas
Apr 3, 2004·American Journal of Ophthalmology·Sushmita KaushikRamandeep Singh
Aug 4, 2004·American Journal of Ophthalmology·Inder P SinghPaul P Lee
Oct 19, 2004·American Journal of Ophthalmology·Shishir AgrawalTrilok Prakash Agrawal
Nov 9, 2004·American Journal of Ophthalmology·Lindsay M SmithenRichard F Spaide
Jan 5, 2005·American Journal of Ophthalmology·Jost B JonasBernd A Kamppeter
Jan 5, 2005·American Journal of Ophthalmology·Jost B JonasImren Akkoyun
Apr 6, 2005·Ophthalmology·Jost B JonasBernd A Kamppeter
Apr 14, 2005·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Abdullah Ozkiriş, Kuddusi Erkiliç
Jul 2, 2005·Korean Journal of Ophthalmology : KJO·Hye Young ParkHa Kyoung Kim
Jul 12, 2005·Progress in Retinal and Eye Research·Jost B JonasRobert Degenring
Jul 19, 2005·The British Journal of Ophthalmology·U H M SpandauJ B Jonas
Aug 23, 2005·The British Journal of Ophthalmology·J García-ArumíE García-Arumí
Mar 2, 2006·Retina·Victoria L MorrisonWilliam R Freeman
Mar 15, 2006·The British Journal of Ophthalmology·B R KosobuckiL Cheng
Apr 7, 2006·The British Journal of Ophthalmology·D J RheeM R Moster
Sep 19, 2006·American Journal of Ophthalmology·François AudrenPascale Massin

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Citations

Jun 19, 2013·Survey of Ophthalmology·Weerawat KiddeeYvonne M Buys
Feb 23, 2010·American Journal of Ophthalmology·Ankur M ShahWilliam R Freeman
Feb 13, 2010·American Journal of Ophthalmology·Tiago Eugênio Faria E ArantesCristina Muccioli
Sep 14, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Ilkay Kilic MuftuogluWilliam R Freeman
Sep 23, 2010·Current Eye Research·G BlatsiosS P Gartaganis

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