Comparison of 48-week efficacies of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide and nucleoside/nucleotide reverse transcriptase inhibitor-sparing regimens: a systematic review and network meta-analysis

HIV Medicine
S GallienE Lazaro

Abstract

To compare nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)-sparing regimens with tenofovir alafenamide (TAF)-based combinations in HIV-1-infected adults, we performed a network meta-analysis (NMA) to provide estimates of relative efficacy for these two regimens. A systematic literature review (SLR) was performed to identify phase 3/4 randomized controlled clinical trials evaluating the efficacy of commonly used combination antiretroviral therapy (cART) including an NRTI backbone or that of commonly used NRTI-sparing regimens. A Bayesian random-effect model was used to compare virological suppression rates at 48 weeks for NRTI-sparing regimens and elvitegravir/cobicistat/emtricitabine/TAF (E/C/F/TAF). Twenty-three studies in treatment-naïve patients identified by the SLR were included in the NMA, including four studies assessing NRTI-sparing regimens. In treatment-naïve patients, the probability of achieving virological suppression at 48 weeks was between 40% and 60% higher with E/C/F/TAF than with NRTI-sparing strategies. The credible interval vs. darunavir/ritonavir (DVR/r) + raltegravir (RAL) and LPV/r monotherapy did not include 1. In the subgroup of naïve patients with viral load < 100 000 HIV-1 RNA copies/mL, ...Continue Reading

References

Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edwin DeJesusUNKNOWN CNA30024 Study Team
Jan 20, 2006·The New England Journal of Medicine·Joel E GallantUNKNOWN Study 934 Group
Sep 13, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·John A BartlettUNKNOWN Clinically Significant Long-Term Antiretroviral Sequential Sequencing Study (CLASS) Team
Aug 26, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rebekah L PulsUNKNOWN Altair Study Group
Sep 16, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace A McComseyTodd T Brown
Mar 26, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew M HallJohn O Connolly
Jun 16, 2011·AIDS·Josep M LlibreUNKNOWN Spanish Group for FDAC Evaluation
Jun 19, 2013·PloS One·Philippe MorlatUNKNOWN Groupe D’epidémiologie Clinique du Sida en Aquitaine (Gecsa)
Nov 8, 2013·The New England Journal of Medicine·Sharon L WalmsleyUNKNOWN SINGLE Investigators
Nov 5, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julia L MarcusMichael J Silverberg
Oct 30, 2016·The Journal of Infectious Diseases·Albert M AndersonUNKNOWN CHARTER Group

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