Comparison of 68Ga PET/CT to Other Imaging Studies in Medullary Thyroid Cancer: Superiority in Detecting Bone Metastases

The Journal of Clinical Endocrinology and Metabolism
Luciana Audi CastronevesAna O Hoff

Abstract

Persistent disease after surgery is common in medullary thyroid cancer (MTC), requiring lifelong radiological surveillance. Staging workup includes imaging of neck, chest, abdomen, and bones. A study integrating all sites would be ideal. Despite the established use of gallium-68 (68Ga) positron emission tomography (PET)/CT with somatostatin analogues in most neuroendocrine tumors, its efficacy is controversial in MTC. Evaluate the efficacy of 68Ga PET/CT in detecting MTC lesions and evaluate tumor expression of somatostatin receptors (SSTRs) associated with 68Ga PET/CT findings. Prospective study evaluating 30 patients with MTC [group 1 (n = 16), biochemical disease; group 2 (n = 14), metastatic disease]. Patients underwent 68Ga PET/CT, bone scan, CT and ultrasound of the neck, CT of the chest, CT/MRI of the abdomen, and MRI of the spine. 68Ga PET/CT findings were analyzed by disease site as positive or negative and as concordant or discordant with conventional studies. Sensitivity and specificity were calculated using pathological or cytological analysis or unequivocal identification by standard imaging studies. Immunohistochemical analysis of SSTRs was compared with 68Ga PET/CT findings. In both groups, 68Ga PET/CT was inferi...Continue Reading

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Citations

Jun 11, 2020·Clinical Nuclear Medicine·Nghi C NguyenAlessandro Furlan
Jul 1, 2020·Annals of Nuclear Medicine·Murat TuncelNilda Süslü
Sep 27, 2018·Frontiers in Pharmacology·Yanhong LuoJianfeng He
Jul 31, 2019·Journal of Thyroid Research·Sergiy V KushchayevOleg M Teytelboym
Jul 23, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Tania JaberMimi I Hu
Feb 7, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Caroline Bodet-MilinFrancoise Kraeber-Bodere
Aug 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Aimee R HayesAshley B Grossman

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