Comparison of 75SeHCAT retention half-life and fecal content of individual bile acids in patients with chronic diarrheal disorders

Digestion
C ScheurlenG Paumgartner

Abstract

Measurement of the retention of 23-75Se-25-homotaurocholic acid (SeHCAT) has been suggested as a new test for ileal function. We investigated 31 patients with chronic diarrhea, 10 with ileal Crohn's disease and 21 with diarrhea but without ileal disease. The whole-body retention half-life of 1 mu Ci SeHCAT was determined and compared to the fecal content of total and individual bile acids. Patients with ileal disease had increased primary fecal bile acids (chenodeoxycholic acid: mean 6.95 mg/g dry weight, range 3.15-10.6 mg/g; cholic acid: mean 18.15 mg/g, range 10.3-33.9 mg/g) and a short SeHCAT retention (mean 11.9 h, range 2-24 h), whereas patients with intact ileum had normal fecal bile acids and a SeHCAT retention of 85.9 h (range 28-216 h). SeHCAT retention half-life differentiated well between patients with ileal disease and patients with normal ileum, thus indicating the SeHCAT test as a valid investigation method for detection of primary bile acid malabsorption in patients with chronic diarrhea and ileal dysfunction.

Citations

Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Jonathan D NolanJulian R F Walters
Jul 1, 1994·The British Journal of Surgery·D ThompsonM A Eastwood
Jun 20, 2020·The American Journal of Gastroenterology·Michael Camilleri, Priya Vijayvargiya
Mar 28, 2018·Current Gastroenterology Reports·Priya Vijayvargiya, Michael Camilleri
Nov 16, 2019·BMC Gastroenterology·Ivan LyutakovRoberto De Giorgio
Dec 31, 2003·Gastroenterology·Gerd A Kullak-UblickPeter J Meier
Nov 10, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Michael Camilleri, Samuel Nurko

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