Comparison of [99m Tc]3PRGD2 Imaging and [18 F]FDG PET/CT in Breast Cancer and Expression of Integrin αv β3 in Breast Cancer Vascular Endothelial Cells

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Zhenying ChenWeibing Miao

Abstract

This study aimed to investigate the value of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) imaging in diagnosis and staging of breast cancer compared with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) imaging, and to explore the expression of integrin αvβ3 in tumor vascular endothelial cells. Forty-two women with suspected breast cancer underwent both [99mTc]3PRGD2 imaging and [18F]FDG imaging. Visual analysis was used to assess primary breast lesion, axillary lymph node, and distant metastasis. The tumor-blood (T/B) ratios from [99mTc]3PRGD2 imaging and the maximum standardized uptake value (SUVmax) from [18F]FDG imaging were analyzed for breast lesions. Integrin αvβ3 was analyzed through immunohistochemistry. Forty-five breast lesions were found (malignant, n = 38; benign, n = 7). The sensitivity, specificity, and accuracy of [99mTc]3PRGD2 and [18F]FDG imaging in visual analysis for the breast lesion were 97.4, 87.5, and 95.6 % and 97.4, 71.4, and 93.3 %, respectively (P > 0.05). For semi-quantitative analysis, no significant difference of the area under the curves (AUC) was found in the imaging using the two radiopharmaceuticals (0.880 and 0.955; Z = 0.88, P > 0.05). The sensitiv...Continue Reading

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References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jun 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·H LiapisS Kitazawa
May 1, 1997·The International Journal of Biochemistry & Cell Biology·M A Horton
May 10, 2000·The Journal of Biological Chemistry·E F PlowJ W Smith
Nov 14, 2001·Seminars in Oncology·R Kumar, R Yarmand-Bagheri
Jan 23, 2003·Cancer Biotherapy & Radiopharmaceuticals·Marcel JanssenOtto C Boerman
Jan 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard L WahlUNKNOWN PET Study Group
Apr 13, 2006·Breast Cancer Research : BCR·Erica K SloanRobin L Anderson
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ambros J BeerMarkus Schwaiger
Aug 10, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bing JiaFan Wang
Aug 30, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Qingjie MaGuoqing Zhao
Nov 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ewelina KluzaKlaas Nicolay
Mar 7, 2012·European Journal of Nuclear Medicine and Molecular Imaging·C RieggerT A Heusner
Apr 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Zhaohui ZhuFang Li
Jun 7, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Johanne SeguinGuy G Chabot
Jun 19, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yang LiFan Wang
May 10, 2013·Clinical Nuclear Medicine·Yuantao HouBing Xing
Jun 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying LiJin Zhang

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