PMID: 11897925Mar 19, 2002Paper

Comparison of a fixed-dose combination of 40 mg telmisartan plus 12.5 mg hydrochlorothiazide with 40 mg telmisartan in the control of mild to moderate hypertension

American Journal of Therapeutics
Yves Lacourcière, Kathryn Martin

Abstract

This study investigated whether a fixed-dose combination of 40 mg of the angiotensin II antagonist telmisartan plus 12.5 mg of the diuretic hydrochlorothiazide (HCTZ) was superior to 40 mg telmisartan in patients with mild to moderate hypertension who failed to respond adequately to 40 mg telmisartan monotherapy. One hundred forty-six patients were withdrawn before randomization. Nonresponders (n = 327) were double blind and randomized to 40 mg telmisartan + 12.5 mg HCTZ (n = 160) or 40 mg telmisartan (n = 167). After 8 weeks of treatment, 40 mg telmisartan + 12.5 mg HCTZ lowered diastolic blood pressure (DBP) by an additional 3.5 mm Hg (P <.01) and systolic blood pressure (SBP) by 7.4 mm Hg (P <.01) compared with 40 mg telmisartan. Most of the additional effect of the combination was seen after 4 weeks of treatment. At week 8, blood pressure was normalized (SBP <140 mm Hg and DBP <90 mm Hg) in 51.6% of patients on 40 mg telmisartan + 12.5 mg HCTZ compared with 23.5% on 40 mg telmisartan (P <.05). The combination of 40 mg telmisartan + 12.5 mg HCTZ normalized DBP in 64.8% of patients, whereas 40 mg telmisartan normalized DBP in 40.1% (P <.05). SBP decreased by > or =10 mm Hg from baseline in 63.5% of patients receiving the fixe...Continue Reading

References

Jan 1, 1985·Drugs·H J GomezJ D Irvin
Oct 1, 1995·American Journal of Hypertension·P A Meredith
Apr 1, 1997·Journal of Human Hypertension·P Marques-Vidal, J Tuomilehto
Nov 3, 1998·American Journal of Hypertension·M R Weir
Jul 29, 1999·American Journal of Therapeutics·J M NeutelG Guthrie
Sep 10, 1999·American Journal of Hypertension·M KocharR A Reeves

❮ Previous
Next ❯

Citations

Jul 20, 2004·Current Hypertension Reports·Irene Gavras, Talma Rosenthal
Oct 9, 2008·Clinical Drug Investigation·Steven G Chrysant
Feb 11, 2010·Current Medical Research and Opinion·Sverre E KjeldsenGiuseppe Mancia
May 20, 2014·Current Medical Research and Opinion·Steen NeldamJoel M Neutel
Oct 12, 2012·Expert Opinion on Pharmacotherapy·L M Ruilope, Helmut Schumacher
Oct 27, 2004·Expert Opinion on Pharmacotherapy·Roland E Schmieder
Nov 25, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hazel Mae A AbrahamWilliam B White
Sep 19, 2002·The Journal of International Medical Research·Y Lacourcière
May 14, 2005·Expert Review of Cardiovascular Therapy·Marc Maillard, Michel Burnier
Jul 31, 2010·Proceedings·Biff F Palmer, Andrew Z Fenves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.