Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

The Veterinary Journal
K S Kalchofner GuerreroR Bettschart-Wolfensberger

Abstract

A newly developed slow-release tablet formulation of metamizole was compared with carprofen for post-operative analgesia in dogs undergoing ovariohysterectomy. Twenty-three dogs were randomly assigned to one of two groups, and administered 50 mg/kg metamizole PO (Group M) or 4 mg/kg carprofen PO (Group C) 1 h before anaesthetic induction and 24 and 48 h later. Anaesthesia was induced with propofol and maintained with isoflurane and fentanyl, after premedication with 0.005 mg/kg medetomidine and 0.3 mg/kg methadone IM. A blinded observer assessed post-operative sedation, and analgesia using a visual analogue scale, a dynamic interactive visual analogue scale, the Glasgow composite pain scale (GCPS), and a mechanical nociceptive threshold device (T = 0.5, 1, 2, 4, 8, 12, 18, 21, 24, 36, 45, 60 and 70 h after surgery). Rescue methadone was administered if the GCPS was >6/24 in ambulatory dogs, or >5/20 in non-ambulatory dogs. Plasma concentrations of test drugs were quantified. The dose range for metamizole was 39-56 mg/kg. At T = 0.5 h sedation scores were significantly higher in Group C and GCPS scores were significantly higher in Group M. Three dogs required rescue methadone (Group M, n = 1; Group C, n = 2). Vomiting occurred p...Continue Reading

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Mar 29, 2014·Veterinary Anaesthesia and Analgesia·Karin S Kalchofner GuerreroRegula Bettschart-Wolfensberger

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Citations

Jan 21, 2018·Journal of Veterinary Pharmacology and Therapeutics·M GiorgiV De Vito
Jun 27, 2018·Journal of Veterinary Pharmacology and Therapeutics·Tae Won KimMario Giorgi
Mar 6, 2019·International Journal of Molecular Sciences·Sergio LópezAnd Mónica Rubio
May 22, 2019·Journal of Feline Medicine and Surgery·Luciana G TeixeiraAndré V Soares
Feb 26, 2019·American Journal of Veterinary Research·Peter R MorreseyEmily A Sundman

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