Comparison of a new office-based stool immunoassay and (13)C-UBT in the diagnosis of current Helicobacter pylori infection

The Journal of Laboratory and Clinical Medicine
I-Chen WuDeng-Chyang Wu

Abstract

Noninvasive methods to diagnose the infection status of Helicobacter pylori were a new developed trend. In this study, the authors sought to investigate the difference between a new office-based stool immunoassay (ImmunoCard STAT! HpSA) and (13)C-Urea Breath Test ((13)C-UBT). We studied 254 dyspeptic patients (159 men, 95 women; mean age=52.8 +/- 14.3 years, range: 19--89 years). All of them underwent gastroendoscopy, (13)C-UBT test, and delivered stool samples within 3 days after endoscopy for the ImmunoCard STAT! HpSA test. The exclusion criteria were those who (1) had received previous anti-Hp treatment, proton pump inhibitor, antibiotics, or bismuth within 1 month of endoscopic examination; (2) had bleeding peptic ulcers; (3) had previously undergone gastric surgery; (4) had long-term use of corticosteroid or immunosuppressant drugs; (5) were pregnant or lactating; and (6) had incomplete data. Hp infection was considered positive when either culture was positive, or both histology and rapid urea test were positive. Those patients were classified as pre- and post-Hp treatment groups. Those in the post-treatment group were patients who received Hp eradication therapy at our hospital more than 2 months ago. The overall sensiti...Continue Reading

References

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Sep 11, 2001·Digestive Diseases·A LeodolterP Malfertheiner
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Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·B HinoRaanan Shamir
Feb 16, 2005·Alimentary Pharmacology & Therapeutics·L TrevisaniV Abbasciano

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Citations

Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
Aug 24, 2006·Helicobacter·Katarzyna Dzierzanowska-FangratDanuta Dzierzanowska
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Feb 19, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Zeki CalikHalil Yazgi

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