Comparison of a novel confocal scanning laser ophthalmoscopy algorithm with optical coherence tomography in measurement of macular thickness and volume

Retina
Byung Ro LeeWilliam R Freeman

Abstract

To evaluate macular thickness and volume measurements using a novel Heidelberg Retinal Tomograph (HRT3) algorithm and to compare the results with optical coherence tomography (StratusOCT). This was a prospective, comparative, clinical noninterventional study. Fifty-two eyes were examined using both methods: 16 normal eyes, 12 eyes with diabetic macular edema (DME), and 24 eyes with age-related macular degeneration (AMD). The HRT3 macular thickness and volume were compared with those from the StratusOCT automated software. In addition, the distances between the retinal surface and the base of subretinal pathologic changes were measured using the StratusOCT manual-caliper technique and were compared with the HRT3 measurements in AMD eyes. No statistically significant difference in macular thickness and volume measurements was observed between the two methods for normal (P = 0.89 and P = 0.33, respectively) and DME eyes (P = 0.86 and P = 0.31, respectively). However, in AMD eyes, the differences in both measurements were statistically significant between the two methods (P < 0.0001 and P < 0.0001, respectively). The HRT3 thickness measurements were in good agreement with the manual StratusOCT measurements (P = 0.4). In normal and ...Continue Reading

References

Jan 1, 1993·Neuroscience and Biobehavioral Reviews·D U Bartsch, W R Freeman
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·J L Demer
Jun 5, 1998·The British Journal of Ophthalmology·C HudsonD McLeod
Nov 26, 1998·The British Journal of Ophthalmology·H J ZambarakjiS A Vernon
Jul 15, 2000·Documenta Ophthalmologica. Advances in Ophthalmology·H J ZambarakjiW M Amoaku
Sep 27, 2000·The British Journal of Ophthalmology·A AngS A Vernon
Aug 14, 2001·Archives of Ophthalmology·P MassinA Gaudric
Sep 10, 2003·Archives of Ophthalmology·Dirk-Uwe G BartschWilliam R Freeman
Jan 28, 2004·Investigative Ophthalmology & Visual Science·Kit GuanJohn G Flanagan
Apr 6, 2004·Journal of Applied Physiology·Franklin SedaratGlen F Tibbits
May 27, 2004·Investigative Ophthalmology & Visual Science·Lelia A PaunescuJames G Fujimoto
Sep 15, 2004·American Journal of Ophthalmology·Robert F DegenringJost B Jonas
Jan 18, 2005·American Journal of Ophthalmology·Robin RayGlenn J Jaffe
Apr 6, 2005·American Journal of Ophthalmology·Aristophanis PallikarisMiltiadis Tsilimbaris
Jun 1, 2005·American Journal of Ophthalmology·Angel Salinas-AlamánAurora Alvárez-Vidal
Aug 23, 2005·The British Journal of Ophthalmology·I KrebsA Goll
Oct 13, 2005·Archives of Ophthalmology·Antonio PolitoFrancesco Bandello
Jan 13, 2006·Ophthalmology·Srinivas R SaddaLaurie D LaBree
Feb 9, 2006·The British Journal of Ophthalmology·A García-LayanaA Fernández-Hortelano
Feb 16, 2006·Archives of Ophthalmology·Annie ChanJoel S Schuman
Aug 2, 2006·Acta Ophthalmologica Scandinavica·Pascale MassinAlain Gaudric
Nov 25, 2006·Ophthalmology·Christopher Kai-shun LeungDennis Shun-chiu Lam

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Citations

Sep 3, 2013·Ophthalmology·Sina FarsiuUNKNOWN Age-Related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
Feb 6, 2017·Retina·Ilkay Kilic MuftuogluWilliam R Freeman

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