Comparison of a respiratory suspension aerosolized by an air-jet and an ultrasonic nebulizer

Pharmaceutical Development and Technology
S L Tiano, R N Dalby

Abstract

In the absence of USP standards and performance monographs, this research sought to determine if differences in the aerosolization mechanism (air-jet vs. ultrasonic) affected droplet and insoluble particle deposition of a nebulized model respiratory suspension. Five milliliters of a model suspension containing 0.1% w/v fluorescein (to estimate droplet deposition) and known quantities of 1, 3, and 6 microns latex spheres (representing insoluble drug particles) was aerosolized from an air-jet and an ultrasonic nebulizer. Nebulized output was collected in a modified Andersen impactor. Samples were analyzed spectrophotometrically (490.5 nm) and by a Coulter Counter to estimate droplet and sphere deposition, respectively. The distribution of droplets throughout the modified impactor for both nebulizers suggested that both the air-jet and the ultrasonic nebulizer produced droplets (0.4 to 10 microns in aerodynamic diameter) large enough to incorporate 1, 3, and 6 microns insoluble spheres. However, Coulter Counter analysis of the sphere distribution revealed that while the air-jet nebulized output contained spheres of all sizes, this was not true for the ultrasonic nebulizer. In the ultrasonic nebulizer, 99% of the spheres (irrespect...Continue Reading

References

Feb 1, 1992·Chest·G F AlvineR C Ahrens
Aug 1, 1990·Critical Care Medicine·D CameronM Silverman
May 1, 1995·The Journal of Allergy and Clinical Immunology·J LefleinS J Szefler

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Citations

Oct 30, 2008·Medicinal Research Reviews·Mark M Bailey, Cory J Berkland
Jul 31, 2012·International Journal of Pharmaceutics·Maha NasrAbdelbary Elhissi
Dec 31, 1997·Equine Veterinary Journal·D H DuvivierP Lekeux

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