Comparison of a second-generation trabecular bypass (iStent inject) to ab interno trabeculectomy (Trabectome) by exact matching.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Y. Al YousefNils A Loewen


To achieve a highly balanced comparison of trabecular bypass stenting (IS2, iStent inject) with ab interno trabeculectomy (T, Trabectome) by exact matching. Fifty-three IS2 eyes were matched to 3446 T eyes. Patients were matched using exact matching by baseline intraocular pressure (IOP), the number of glaucoma medications, and glaucoma type, and using nearest neighbor matching by age. Individuals without a close match were excluded. All surgeries were combined with phacoemulsification. A total of 78 eyes (39 in each group) could be matched as exact pairs with a baseline IOP of 18.3 ± 5.1 mmHg and glaucoma medications of 2.7 ± 1.2 in each. IOP in IS2 was reduced to 14.6 ± 4.2 mmHg at 3 months and in T to a minimum of 13.1 ± 3.2 mmHg at 1 month. In IS2, IOP began to rise again at 6 months, eventually exceeding baseline. At 24 months, IOP in IS2 was 18.8 ± 9.0 mmHg and in T 14.2 ± 3.5 mmHg. IS2 had a higher average IOP than T at all postoperative visits (p < 0.05 at 1, 12, 18 months). Glaucoma medications decreased to 2.0 ± 1.5 in IS2 and to 1.5 ± 1.4 in T. T resulted in a larger and sustained IOP reduction compared with IS2 where a rebound occurred after 6 months to slightly above preoperative values.


Jun 1, 1988·Experimental Eye Research·M E Sherwood, T M Richardson
Jun 1, 2002·Human Immunology·J Wayne StreileinTakeshi Kezuka
Nov 12, 2002·International Reviews of Immunology·Joan Stein-Streilein, J Wayne Streilein
May 11, 2005·Ophthalmology·Don S MincklerBrian A Francis
Jun 24, 2008·Journal of Cataract and Refractive Surgery·Brian A FrancisTrabectome Study Group
Aug 30, 2014·The British Journal of Ophthalmology·Igor I BusselTrabectome Study Group
Oct 23, 2014·The British Journal of Ophthalmology·Igor I BusselTrabectome Study Group
Oct 4, 2015·Journal of Cataract and Refractive Surgery·Michelle KhanIqbal Ike K Ahmed
Jan 7, 2016·The British Journal of Ophthalmology·Kevin KaplowitzNils A Loewen
Feb 27, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Khaliq KurjiMichael W Dorey
May 23, 2017·F1000Research·Katherine FallanoNils A Loewen
Mar 30, 2018·American Journal of Speech-language Pathology·Charles R GreenwoodJudith J Carta
Apr 11, 2018·American Journal of Physiology. Cell Physiology·Fiona McDonnellW Daniel Stamer
May 4, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yalong DangNils A Loewen
Jun 13, 2018·Journal of Cataract and Refractive Surgery·Manjool ShahIqbal Ike K Ahmed
Jul 3, 2018·Journal of Glaucoma·Cara E Capitena YoungMalik Y Kahook
Apr 30, 2019·Journal of Cataract and Refractive Surgery·Hamed EsfandiariNils A Loewen


Dec 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A. StrzalkowskaNils A Loewen

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