Comparison of a therapeutic-only versus prophylactic platelet transfusion policy for people with congenital or acquired bone marrow failure disorders.

The Cochrane Database of Systematic Reviews
Reem MaloufLise J Estcourt

Abstract

Bone marrow disorders encompass a group of diseases characterised by reduced production of red cells, white cells, and platelets, or defects in their function, or both. The most common bone marrow disorder is myelodysplastic syndrome. Thrombocytopenia, a low platelet count, commonly occurs in people with bone marrow failure. Platetet transfusions are routinely used in people with thrombocytopenia secondary to bone marrow failure disorders to treat or prevent bleeding. Myelodysplastic syndrome is currently the most common reason for receiving a platelet transfusion in some Western countries. To determine whether a therapeutic-only platelet transfusion policy (transfusion given when patient is bleeding) is as effective and safe as a prophylactic platelet transfusion policy (transfusion given to prevent bleeding according to a prespecified platelet threshold) in people with congenital or acquired bone marrow failure disorders. We searched for randomised controlled trials (RCTs), non-RCTs, and controlled before-after studies (CBAs) in the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library 2017, Issue 9), Ovid MEDLINE (from 1946), Ovid Embase (from 1974), PubMed (e-publications only), the Transfusion Evid...Continue Reading

References

Oct 1, 1990·Transfusion Medicine Reviews·T S Kickler
Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A SchifferUNKNOWN American Society of Clinical Oncology
May 3, 1962·The New England Journal of Medicine·L A GAYDOSN MANTEL
Jul 13, 2004·Transfusion Medicine Reviews·Sherrill J Slichter
Oct 29, 2005·Blood·Surapol IssaragrisilNeal S Young
Jan 28, 2006·Mayo Clinic Proceedings·David P Steensma, John M Bennett
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie-Cécile Le DeleyCatherine Hill
Mar 17, 2007·Cancer·Hagop KantarjianJoseph Leveque
Apr 25, 2007·Acta Clinica Belgica·A BoslyD Sondag
Mar 7, 2008·Haematologica·Eva MontanéUNKNOWN Catalan Group for Study of Agranulocytosis and Aplastic Anemia
Apr 2, 2008·Haematologica·Neal S Young, David W Kaufman
May 31, 2008·British Journal of Haematology·Eldad Hod, Joseph Schwartz
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Sep 1, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Anupam Verma, Prashant Agarwal
Dec 17, 2009·Hematology·Akiko Shimamura
Feb 19, 2010·The New England Journal of Medicine·Sherrill J SlichterSuzanne Granger
Apr 3, 2010·Hematology/oncology Clinics of North America·Mikkael A Sekeres
May 27, 2010·F1000 Medicine Reports·Neil BlumbergGordon L Phillips
Feb 10, 2011·Transfusion·Alice K FullerKaren E King
Mar 1, 2011·Virology Journal·Bisma RauffMuhammad Ali
Jun 29, 2011·Leukemia Research·Judith NeukirchenUlrich Germing
Jun 15, 2012·American Journal of Hematology·Guillermo Garcia-Manero
Jun 29, 2012·The American Journal of Medicine·Xiaomei Ma
Aug 30, 2012·British Journal of Haematology·Hazel TinegateUNKNOWN BCSH Blood Transfusion Task Force
Jan 12, 2013·Transfusion·Lise J EstcourtUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative
May 10, 2013·The New England Journal of Medicine·Simon J StanworthUNKNOWN TOPPS Investigators
Jul 4, 2013·Nature Reviews. Clinical Oncology·Charles A Schiffer
Jan 1, 2014·British Journal of Haematology·Sally B KillickUNKNOWN British Committee for Standards in Haematology
Jan 7, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Avinash G DinmohamedMojca Jongen-Lavrencic
Nov 11, 2014·Annals of Internal Medicine·Richard M KaufmanAaron A R Tobian

❮ Previous
Next ❯

Citations

Aug 14, 2020·Vox Sanguinis·Julie MoracchiniPierre Tiberghien
Sep 12, 2020·Acta Anaesthesiologica Scandinavica·Andreas Bender JonssonLene Russell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.