Comparison of Abbott AxSYM and Roche Elecsys 2010 for measurement of BNP and NT-proBNP

Clinica Chimica Acta; International Journal of Clinical Chemistry
Tzu-I ChienJau-Tsuen Kao

Abstract

B-type natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are small cardiac hormones released from the heart. They can be used as an important aid to diagnose congestive heart failure (CHF). We compared the performances of the Abbott AxSYM and Roche Elecsys 2010 for the measurement of BNP and NT-proBNP. The first method uses a microparticle enzyme-linked immunoassay, whereas the other uses chemiluminescent immunometric assay. The CVs using pooled sera ranged from 3.7% to 12.7% for the AxSYM and 0.9% to 2.2% for the Elecsys 2010. The Passing and Bablok regression was Elecsys 2010 NT-proBNP=7.23xAxSYM BNP+2.53. The BNP in EDTA plasma was more stable than in serum. The immunoreactivity difference of NT-proBNP in serum or EDTA plasma was within 10% when stored at 4 degrees Celsius or 25 degrees Celsius for 72 h. Receiver operating characteristic (ROC) curves were different for both assays, and the areas under the curves were 0.704 and 0.841 for the AxSYM and Elecsys 2010 method, respectively. Both assays were not entirely specific for heart failure. The precision and stability for NT-proBNP was better than for BNP in serum. It is important to use method-appropriate reference ranges (or cutoff) for th...Continue Reading

References

Nov 1, 1983·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H Passing, Bablok
Apr 1, 1994·Journal of Hypertension·N C Davidson, A D Struthers
Jun 1, 1994·Journal of Internal Medicine·T G Yandle
Sep 11, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·H ShimizuH Teraoka
Jan 5, 2000·BMJ : British Medical Journal·R C DavisG Y Lip
Aug 9, 2001·European Heart Journal·W J RemmeUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology
Sep 13, 2002·Journal of the American College of Cardiology·Margaret M RedfieldJohn C Burnett
May 27, 2003·Clinical Chemistry·Amitava DasguptaLupe Nazareno
Dec 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Steven J SoldinMadeline S Taskier

❮ Previous
Next ❯

Citations

Aug 11, 2007·Analytical and Bioanalytical Chemistry·N DelmotteC G Huber
May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Cecile GorissenMathie Leers
Jul 25, 2012·The American Journal of Tropical Medicine and Hygiene·Stuart D BlacksellPaul N Newton
Jun 24, 2008·Acute Cardiac Care·Bo HanYonathan Hasin
Apr 2, 2008·International Journal of Cardiology·Johannes Steiner, Maya Guglin
Jun 8, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Ana Catarina FonsecaJosé M Ferro
Jul 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jessie Shih, Robert M Olson
Oct 24, 2007·Acta Anaesthesiologica Scandinavica·S B ElíasdóttirF Valsson
Dec 31, 2014·Critical Reviews in Clinical Laboratory Sciences·Aldo ClericoClaudio Passino
Oct 7, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christian Löwbeer, Hans Wallinder
Jul 17, 2007·Journal of the American College of Cardiology·Torbjørn OmlandUNKNOWN PEACE Investigators
May 31, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·JianQing SongQiHui Wang
Aug 29, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Ana Catarina FonsecaJosé M Ferro
Apr 26, 2011·Anesthesia and Analgesia·Amanda A Fox, Simon C Body
Mar 8, 2013·Acta Neurologica Scandinavica·A C FonsecaJ M Ferro
Jan 22, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Angelika Hammerer-LercherPäivi Laitinen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.