Comparison of acebutolol and hydrochlorothiazide in essential hypertension

American Heart Journal
J E Lewis


In a multicenter, double-blind comparison of acebutolol and hydrochlorothiazide in patients with mild to moderate essential hypertension (diastolic blood pressure, 95 to 114 mm Hg) in 182 and 178 patients, respectively, each agent reduced systolic and diastolic pressures to a similar significant degree: acebutolol, 15.9 and 14.9 mm Hg; hydrochlorothiazide, 15.2 and 13.3 mm Hg (p less than 0.001 vs baseline). Acebutolol significantly reduced heart rate by 8.9 bpm at the end of dose titration (p = 0.001), with no further decrease seen during maintenance. Fourteen patients on each treatment regimen were discontinued from the study because of side effects. However, significantly more hydrochlorothiazide patients experienced side effects of arrhythmia, anorexia, and flatulence; in addition, more hydrochlorothiazide patients developed abnormal levels of serum glucose, uric acid, blood urea nitrogen, serum potassium, and chloride. In a single-center study of patients who remained hypertensive while receiving diuretics, six of nine patients receiving acebutolol concomitantly with a diuretic responded (seated diastolic blood pressure reduced below 90 mm Hg), whereas no patients receiving placebo and diuretic concomitantly responded (p l...Continue Reading


Oct 14, 1977·European Journal of Clinical Pharmacology·L HanssonM Holm
Dec 1, 1975·British Heart Journal·C J Bulpitt
Jan 1, 1982·Journal of Cardiovascular Pharmacology·B F Johnson
Feb 24, 1983·The American Journal of Cardiology·N M Kaplan
Mar 1, 1980·The American Journal of Cardiology·L R KrakoffK R Felton
Apr 1, 1981·The American Journal of Medicine·O B HollandL Kuhnert

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Jan 1, 1986·Current Medical Research and Opinion·H R Lubis Yushar
May 30, 2014·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright

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