PMID: 8608684Nov 1, 1995Paper

Comparison of aceclofenac with diclofenac in the treatment of osteoarthritis

Clinical Rheumatology
D E WardJ Roma

Abstract

A multicentre randomised, double-blind, parallel group, general practice study was undertaken to investigate the efficacy and safety of aceclofenac (200 patients, 100 mg twice daily and placebo once daily) in comparison with diclofenac (197 patients, 50mg three times daily) in patients with osteoarthritis of the knee. The treatment period of twelve weeks was preceded by a washout period of two weeks duration. At end point, patients in both aceclofenac and diclofenac-treated groups exhibited significant improvement in pain intensity (p = 0.0001). Although both treatment groups showed significant improvement in all investigators' clinical assessments (joint tenderness, swelling, pain on movement, functional capacity, overall assessment), there were no significant differences between the groups. There was, however, a trend towards greater improvement in complete knee movement and reduced pain on movement with aceclofenac. In patients with initial flexion deformity, aceclofenac was significantly more effective than diclofenac in improving knee flexion after 2-4 weeks treatment. Patients' subjective assessment of pain relief demonstrated significantly greater efficacy with aceclofenac. At end point, 71% of patients in the aceclofena...Continue Reading

References

Feb 1, 1991·Drugs·A al Arfag, P Davis
Dec 1, 1987·Archives of Internal Medicine·S H Roth, R E Bennett
Apr 28, 1986·The American Journal of Medicine·R Altman

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Citations

Jul 1, 1996·Clinical Rheumatology·J A HunterX G Balaguer
May 10, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alaa RostomLoren Laine
Jul 22, 2014·BioMed Research International·Kaisar RazaO P Katare
Mar 1, 1997·Clinical Rheumatology·M Peréz BusquierM Alepuz Pou
May 28, 2004·Expert Opinion on Pharmacotherapy·Erik Legrand
Jul 19, 2012·Journal of Separation Science·Eunyoung KimHye sun Gwak

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