Comparison of acid-base models for prediction of hospital mortality after trauma

Shock
Lewis J Kaplan, John A Kellum

Abstract

This study determines whether mortality after major trauma is predicted by the strong ion gap (SIG) and whether recent refinements in the calculation of SIG improve its predictive value. The design was an observational, retrospective review of trauma patients admitted on a single service at a level 1 facility. The setting was an urban level 1 trauma facility. An unselected cohort of patients sustaining blunt and/or penetrating injury requiring intensive care unit care was chosen. There were no interventions. Age, injury mechanism, survival, arterial blood gases, hemoglobin, albumin, electrolytes, lactate, standard base deficit, strong ion difference (SID), buffer base, and SIG were analyzed. Patients were grouped into survivors and nonsurvivors according to in-hospital survival truncated to 28 days. Multivariate logistic regression was used for further analysis of univariate predictors of mortality, and receiver-operator characteristic curves were generated for mortality. Both nonsurvivors (n = 26) and survivors (n = 52) were similar with respect to age (31.9 +/- 11.5 vs. 33.5 +/- 11.6 years) and injury mechanism (blunt 61% vs. 58%) Nonsurvivors were more likely to have multicavity injury (54% vs. 26%; P < 0.01) than survivors....Continue Reading

References

Dec 1, 1983·Canadian Journal of Physiology and Pharmacology·P A Stewart
Jun 1, 1995·Journal of Critical Care·J A KellumM R Pinsky
Jun 1, 1995·Journal of Applied Physiology·J A KellumM R Pinsky
Oct 1, 1993·The Journal of Trauma·D AbramsonJ Greenspan
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·A PedotoT S Hakim
Apr 8, 1999·Journal of Applied Physiology·P D Watson
Feb 28, 2001·Shock·D RixenUNKNOWN Arbeitsgemeinschaft "Polytrauma" of the Deutsche Gesellschaft fur Unfallchirurgie
Feb 21, 2003·Intensive Care Medicine·Mark HatherillAndrew Argent
Apr 1, 2003·Journal of Applied Physiology·Henry R Staempfli, Peter D Constable
Jun 10, 2003·Critical Care : the Official Journal of the Critical Care Forum·Mirjam MoviatHans van der Hoeven
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Jens RocktaeschelRinaldo Bellomo
Sep 16, 2003·Critical Care Medicine·Jens RocktaeschelRinaldo Bellomo
Dec 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John A KellumJinyou Li
Aug 3, 2004·Critical Care Medicine·Arjen M DondorpNicholas P J Day
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Andrew DurwardIan A Murdoch
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Lui G ForniPhilip J Hilton
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·John A Kellum
Jan 21, 2006·Journal of Applied Physiology·Henry StämpfliPeter D Constable
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Kyle J GunnersonJohn A Kellum

❮ Previous
Next ❯

Citations

Dec 29, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Ole KruseCharlotte Barfod
Nov 12, 2013·Revista Brasileira de terapia intensiva·Fernando Godinho ZampieriFabiano Pinheiro da Silva
Apr 14, 2016·Journal of Clinical Monitoring and Computing·Thomas J MorganMatthew B Wolf
Oct 8, 2009·Paediatric Anaesthesia·Christian MannOskar Baenziger
Jun 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Asghar Rastegar
Jul 1, 2014·Shock·Afshin ParsikiaAmit R T Joshi
Nov 22, 2012·Anesthesiology·Marie-Alix RégnierBruno Riou
May 14, 2020·Surgical Infections·Joseph S Fernandez-MoureJohn P Fischer
Mar 13, 2021·Journal of Veterinary Emergency and Critical Care·Alex Louis BlutingerJennifer Prittie
Nov 6, 2020·The American Journal of Emergency Medicine·Amin GharipourDavid Mukasa
Apr 2, 2021·Emergency Medicine Journal : EMJ·Andrew R CogginsJeremy M Hsu
Nov 4, 2020·Journal of Veterinary Internal Medicine·Diego E GomezDavid L Renaud
Apr 30, 2021·Journal of Emergencies, Trauma, and Shock·Demi BeneruAndrew R Coggins
May 23, 2008·Shock·Mark G Clemens
Nov 28, 2009·Journal of Critical Care·Kyle J GunnersonJohn A Kellum
Jun 12, 2010·The Journal of Trauma·Joel Avancini Rocha FilhoJosé O C Auler
Jul 9, 2010·Current Opinion in Critical Care·Lewis J Kaplan, John A Kellum
Sep 30, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F O MarquesE F Daher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.