Comparison of active vitamin D compounds and a calcimimetic in mineral homeostasis.

Journal of the American Society of Nephrology : JASN
Loan Nguyen-YamamotoDavid Goltzman

Abstract

The differential effects between cinacalcet and active vitamin D compounds on parathyroid function, mineral metabolism, and skeletal function are incompletely understood. Here, we studied cinacalcet and active vitamin D compounds in mice expressing the null mutation for Cyp27b1, which encodes 25-hydroxyvitamin D-1α-hydroxylase, thereby lacking endogenous 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. Vehicle-treated mice given high dietary calcium had hypocalcemia, hypophosphatemia, and marked secondary hyperparathyroidism. Doxercalciferol and 1,25(OH)(2)D(3) each normalized these parameters and corrected both the abnormal growth plate architecture and the diminished longitudinal bone growth observed in these mice. In contrast, cinacalcet suppressed serum parathyroid hormone (PTH) cyclically and did not correct the skeletal abnormalities and hypocalcemia persisted. Vehicle-treated mice given a "rescue diet" (high calcium and phosphorus, 20% lactose) had normal serum calcium and PTH levels; cinacalcet induced transient hypocalcemia and mild hypercalciuria. The active vitamin D compounds and cinacalcet normalized the increased osteoblast activity observed in mice with secondary hyperparathyroidism; cinacalcet, however, increased t...Continue Reading

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Nov 1, 1986·The Journal of Clinical Investigation·J SilverM M Popovtzer
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G HouseE M Brown
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·E F NemethM F Balandrin
May 8, 1998·Biochemical and Biophysical Research Communications·T KamedaM Kumegawa
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·D K PandaD Goltzman
Nov 15, 2001·Reviews in Endocrine & Metabolic Disorders·E M Brown
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Edward F NemethDavid Martin
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melita M DvorakDaniela Riccardi
Apr 9, 2004·The New England Journal of Medicine·Geoffrey A BlockWilliam G Goodman
Apr 16, 2004·Endocrinology·Naibedya ChattopadhyayEdward M Brown
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jack W CoburnCharles W Bishop
Oct 4, 2005·The Journal of Biological Chemistry·Min PiL Darryl Quarles
Oct 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rana SamadfamDavid Goltzman
Aug 2, 2007·The Journal of Clinical Endocrinology and Metabolism·S J SilverbergJ P Bilezikian
Feb 2, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Dennis L AndressStuart M Sprague
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Uri S AlonL Darryl Quarles
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter W JurutkaMark R Haussler
Oct 13, 2009·Endocrinology·Rana SamadfamDavid Goltzman
Mar 5, 2010·American Journal of Physiology. Renal Physiology·Jane L FinchEduardo Slatopolsky
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian RichardDavid Goltzman

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Citations

Feb 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katherine Wesseling-Perry, Isidro B Salusky
Jan 26, 2012·American Journal of Physiology. Endocrinology and Metabolism·Yingben XueDavid Goltzman
May 23, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sandra M SaccoWendy E Ward
Mar 11, 2015·Nature Reviews. Endocrinology·David Goltzman, Geoffrey N Hendy
Jul 1, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie BernardorJustine Bacchetta

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