Comparison of adjunctive use of rofecoxib versus ibuprofen in the management of postoperative pain after uterine artery embolization

Journal of Vascular and Interventional Radiology : JVIR
David M HovsepianTirath Patel

Abstract

The primary purpose of the present study was to compare the antiinflammatory effectiveness of rofecoxib with that of ibuprofen in the first 5 days after uterine artery embolization (UAE). The secondary aim was to compare pain levels and narcotic use among patients treated with different embolic agents. From July 2003 to June 2004, 68 UAE procedures were performed by one of the authors (D.M.H.). Of this group, 50 women agreed to participate in this study. Exclusion criteria were limited to contraindication to either drug or current steroid or nonsteroidal antiinflammatory drug use. In a randomized, double-blinded fashion, patients received a numbered pill box that contained one of the two agents and its placebo counterpart. Four times per day for 5 days, patients recorded their level of pain on a visual analog scale and the amount of narcotic analgesic drug needed at that time. Score sheets were returned by mail after completion. During the course of the study, three embolic agents (Gold Embospheres, Contour SE particles, and Embospheres) were used in succession, with similar numbers of patients in each group. Four patients were excluded from analysis: two who were readmitted to the hospital for treatment of pain (one treated wi...Continue Reading

References

Aug 9, 2001·Journal of Clinical Pharmacy and Therapeutics·R B Raffa
Oct 11, 2003·Journal of Vascular and Interventional Radiology : JVIR·Gaylene PronUNKNOWN Ontario UFE Collaborative Group
Aug 7, 2004·Journal of Vascular and Interventional Radiology : JVIR·Jill BrunoJames B Spies
Dec 14, 2004·Journal of Vascular and Interventional Radiology : JVIR·Pasteur RasuliMohamed Tabib
Feb 17, 2005·The New England Journal of Medicine·Robert S BresalierUNKNOWN Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators

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