Abstract
This was a nation-wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB-IIB cervical cancer with pelvic and/or para-aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death and patterns of disease recurrence were compared based upon the adjuvant treatment pattern: whole pelvic radiotherapy alone (n = 253), concurrent chemoradiotherapy (CCRT, n = 502) and chemotherapy alone (n = 319). Women who received chemotherapy alone had similar recurrence (5-year rates, 36.6% vs. 34.1%, adjusted-hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.70-1.28, P = 0.72) and cervical cancer mortality (24.7% vs. 21.8%, adjusted-HR 0.96, 95% CI 0.67-1.38, P = 0.83) rates compared to those who received CCRT on multivariate analysis. However, when recurrence patterns were stratified, chemotherapy treatment was independently associated with decreased risk of distant recurrence (5-year cumulative rates, 19.2% vs. 24.6%, adjusted-HR 0.47, 95% CI 0.31-0.71, P < 0.001) but increased risk of local recurrence (23.9% vs. 14.3%, adjusted-HR 2.03, 95% CI 1.34-3.08, P = 0.001) compared to CCRT. Non-squamous histology, parametrial involvement and high lymph node ratio were independen...Continue Reading
References
Sep 1, 1990·Gynecologic Oncology·G DelgadoF Major
Aug 23, 1997·Lancet·F LandoniC Mangioni
May 18, 1999·Gynecologic Oncology·A SedlisR J Zaino
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P CurtinR D Alvarez
Jul 5, 2003·Lancet·Steven E Waggoner
Feb 22, 2005·Gynecologic Oncology·Shoji NagaoIchiro Kohno
Jul 30, 2005·Gynecologic Oncology·E KastritisM A Dimopoulos
Aug 27, 2005·Japanese Journal of Clinical Oncology·Teruki Teshima, UNKNOWN Japanes PCS Working Group
Jan 24, 2006·International Journal of Radiation Oncology, Biology, Physics·Marvin RotmanRichard J Zaino
Jun 17, 2006·Gynecologic Oncology·Nobuhiro TakeshimaKatsuhiko Hasumi
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
Oct 20, 2007·BMJ : British Medical Journal·Erik von ElmUNKNOWN STROBE Initiative
Oct 22, 2008·The Journal of Obstetrics and Gynaecology Research·Masayoshi HosakaNoriaki Sakuragi
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Oct 15, 2010·Cancer·Nora T KizerPerry W Grigsby
Dec 15, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Benjamin E GreerUNKNOWN National Comprehensive Cancer Networks
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Nov 9, 2011·Journal of Surgical Oncology·Masayoshi HosakaNoriaki Sakuragi
Jan 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Natsuo TomitaMichihide Mitsumori
Mar 7, 2013·British Journal of Cancer·K MatsuoT Kimura
Sep 24, 2013·PloS One·Shuang LiDing Ma
Dec 3, 2014·Gynecologic Oncology·Nicole D FlemingPedro T Ramirez
Jul 16, 2015·PloS One·Phill-Seung JungJoo-Hyun Nam
May 21, 2016·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Hiroshi AsanoHidemichi Watari
Jun 25, 2016·The Journal of Obstetrics and Gynaecology Research·Toshiaki Saito, Hidetaka Katabuchi
Jul 9, 2016·BMC Cancer·Lei LiLiYing Wang
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
Citations
Mar 27, 2018·Cancer Science·Munetaka TakekumaKimihiko Ito
Dec 1, 2017·Journal of Gynecologic Oncology·Koji MatsuoToru Sugiyama
Dec 1, 2017·Journal of Gynecologic Oncology·Kwang Beom LeeJong Min Lee
Dec 1, 2017·Journal of Gynecologic Oncology·Koji MatsuoMikio Mikami
Feb 16, 2018·International Journal of Clinical Oncology·Mika Okazawa-SakaiKazuhiro Takehara
Jan 8, 2019·PloS One·Hiroko MachidaMikio Mikami
Jan 23, 2019·Japanese Journal of Clinical Oncology·Xiaoliang LiuKe Hu
May 15, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Dec 24, 2019·Japanese Journal of Clinical Oncology·Muneaki ShimadaNobuo Yaegashi
Jan 2, 2018·Oncotarget·Koji MatsuoToru Sugiyama
Jun 18, 2020·Cancers·Luigi Pedone AnchoraGabriella Ferrandina
Aug 28, 2020·Journal of Oncology·Marina A SenchukovaNadezhda N Volchenko
May 18, 2018·Journal of Gynecologic Oncology·Kwang Beom LeeJong Min Lee
May 29, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Feb 2, 2019·Journal of Clinical Medicine·Koji MatsuoToru Sugiyama
Jan 17, 2020·Scientific Reports·Xiaoliang LiuWenhui Wang
Apr 9, 2020·Journal of Gynecologic Oncology·Noriaki SakuragiHidemichi Watari
Aug 8, 2020·BMC Cancer·Hideki MatsuokaMasaki Mandai
Mar 20, 2019·Journal of Gynecologic Oncology·Hiroyuki KanaoNobuhiro Takeshima
Sep 13, 2018·Journal of Gynecologic Oncology·Tomone WatanabeTakahiro Higashi
Apr 28, 2019·Medicine·Jinfei TongJianhua Yang
Nov 7, 2019·Journal of Clinical Medicine·Koji MatsuoMikio Mikami
Oct 30, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Masao OkadomeToshiaki Saito
Sep 4, 2020·International Journal of Clinical Oncology·Kaoru OkugawaKiyoko Kato
Dec 15, 2020·The Tohoku Journal of Experimental Medicine·Muneaki ShimadaNobuo Yaegashi
Mar 6, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Akiko FurusawaTakayuki Enomoto
Mar 21, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Koji MatsuoMikio Mikami
Apr 8, 2021·Journal of Gynecologic Oncology·Masae IkedaMikio Mikami
Apr 8, 2021·International Journal of Clinical Oncology·Kazuhiro SuzukiSatoshi Yamaguchi
Apr 29, 2021·Journal of Gynecologic Oncology·Alyssa C Bujnak, Krishnansu S Tewari
May 4, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Fatih KilicOsman Turkmen
May 19, 2021·The Journal of Obstetrics and Gynaecology Research·Takashi ShibutaniSatoshi Yamaguchi
May 22, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Koji MatsuoLynda D Roman
Jun 3, 2021·Medicina·Masahiro KagabuTsukasa Baba
Oct 5, 2021·Technology in Cancer Research & Treatment·Guangyu ZhangChunli Fu
Dec 16, 2021·The Journal of Obstetrics and Gynaecology Research·Muneaki ShimadaNobuo Yaegashi