Comparison of adjuvant therapy for node-positive clinical stage IB-IIB cervical cancer: Systemic chemotherapy versus pelvic irradiation

International Journal of Cancer. Journal International Du Cancer
K MatsuoToru Sugiyama

Abstract

This was a nation-wide retrospective study in Japan examining women who underwent radical hysterectomy for clinical stage IB-IIB cervical cancer with pelvic and/or para-aortic lymph node metastasis between 2004 and 2008. Time to recurrence or death and patterns of disease recurrence were compared based upon the adjuvant treatment pattern: whole pelvic radiotherapy alone (n = 253), concurrent chemoradiotherapy (CCRT, n = 502) and chemotherapy alone (n = 319). Women who received chemotherapy alone had similar recurrence (5-year rates, 36.6% vs. 34.1%, adjusted-hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.70-1.28, P = 0.72) and cervical cancer mortality (24.7% vs. 21.8%, adjusted-HR 0.96, 95% CI 0.67-1.38, P = 0.83) rates compared to those who received CCRT on multivariate analysis. However, when recurrence patterns were stratified, chemotherapy treatment was independently associated with decreased risk of distant recurrence (5-year cumulative rates, 19.2% vs. 24.6%, adjusted-HR 0.47, 95% CI 0.31-0.71, P < 0.001) but increased risk of local recurrence (23.9% vs. 14.3%, adjusted-HR 2.03, 95% CI 1.34-3.08, P = 0.001) compared to CCRT. Non-squamous histology, parametrial involvement and high lymph node ratio were independen...Continue Reading

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Citations

Feb 16, 2018·International Journal of Clinical Oncology·Mika Okazawa-SakaiKazuhiro Takehara
May 15, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Dec 24, 2019·Japanese Journal of Clinical Oncology·Muneaki ShimadaNobuo Yaegashi
May 29, 2019·Obstetrics and Gynecology·Koji MatsuoMikio Mikami
Apr 9, 2020·Journal of Gynecologic Oncology·Noriaki SakuragiHidemichi Watari
Sep 13, 2018·Journal of Gynecologic Oncology·Tomone WatanabeTakahiro Higashi
Oct 30, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Masao OkadomeToshiaki Saito
Sep 4, 2020·International Journal of Clinical Oncology·Kaoru OkugawaKiyoko Kato
Dec 15, 2020·The Tohoku Journal of Experimental Medicine·Muneaki ShimadaNobuo Yaegashi
Mar 6, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Akiko FurusawaTakayuki Enomoto
Mar 21, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Koji MatsuoMikio Mikami
Apr 8, 2021·International Journal of Clinical Oncology·Kazuhiro SuzukiSatoshi Yamaguchi
May 4, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Fatih KilicOsman Turkmen
May 19, 2021·The Journal of Obstetrics and Gynaecology Research·Takashi ShibutaniSatoshi Yamaguchi
May 22, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Koji MatsuoLynda D Roman
Dec 16, 2021·The Journal of Obstetrics and Gynaecology Research·Muneaki ShimadaNobuo Yaegashi

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