Comparison of adrenergic receptor binding in blood cells from alcoholics and controls

Alcohol
D B BylundR A Harris

Abstract

Ethanol inhibited in vitro alpha-2 adrenergic receptor binding in platelets with an IC50 of 380 mM and beta adrenergic receptor binding in lymphocytes and polymorphonuclear leucocytes with IC50 values of about 1 M. The characteristics of alpha-2 receptor binding were similar in platelets from chronic alcoholics and from non-alcoholics. The densities of beta adrenergic receptors were similar in blood cells from alcoholics and controls, although there were some changes in receptor affinities. Thus, chronic alcohol consumption does not appear to have a substantial effect on adrenergic receptor binding in blood cells.

References

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Citations

Aug 19, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·J D DeupreeUNKNOWN UNMC Collaborative ADHD Research Team
Sep 24, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seppo Kähkönen
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·A J SmithA Foy

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