Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance.

AIDS
Lin LiuDavey M Smith

Abstract

We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance. Retrospective cohort study. For the International AIDS Society-USA method we classified a mutation as resistant if it was a 'major' resistance-associated mutation. For the Stanford algorithm, we classified a mutation as resistant if the score was at least 60 (Stanford 60), and alternatively, if the score was at least 30 (Stanford 30). For Agence Nationale de Recherches sur le SIDA and Rega, we interpreted resistance as either 'intermediate resistance' or 'resistance' (ANRS 1 and Rega 1), and 'resistance' only (ANRS 2 and Rega 2). We also used the calibrated population resistance algorithm. We then determined the rates of transmitted drug resistance within the Acute Infection Early Disease Research Program cohort (n = 1311) enrolled between March 1995 and August 2006 using each method; agreement was assessed using kappa coefficients. Differences in estimated rates of transmitted drug resistance using International AIDS Society-USA, calibrated population resistance, Stanford 30, ANRS 1, Rega 1 and Rega 2 methods were mostly minor for resistance to protease and non-nucleoside rever...Continue Reading

References

Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G Garcia-LermaW Heneine
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Robert M GrantJames O Kahn
Aug 9, 2002·The New England Journal of Medicine·Susan J LittleDouglas D Richman
Jan 10, 2003·Nucleic Acids Research·Soo-Yon RheeRobert W Shafer
Nov 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bernard MasquelierUNKNOWN CASCADE Collaboration
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA panel
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Davey SmithSusan Little

❮ Previous
Next ❯

Citations

Jun 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin S HirschDouglas D Richman
Apr 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sergei L Kosakovsky Pond, Davey M Smith
Oct 28, 2010·AIDS Research and Human Retroviruses·Sanjay R MehtaDavey M Smith
Oct 26, 2012·BMC Research Notes·Awachana JiamsakulUNKNOWN TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M)
Jul 7, 2015·Journal of Medical Virology·Awachana JiamsakulUNKNOWN TREAT Asia Studies to Evaluate Resistance--Monitoring Study TASER-M
May 23, 2014·Drug Discovery Today. Technologies·Pablo Carbonell, Jean-Yves Trosset
Jun 19, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen A HartLinda J Harrison
Jan 15, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Agnès DepatureauxJean-Christophe Plantier
Mar 25, 2014·Current HIV/AIDS Reports·Fumiyo NakagawaJens D Lundgren
Oct 2, 2008·HIV Medicine·B G GazzardUNKNOWN BHIVA Treatment Guidelines Writing Group
Feb 13, 2010·Physiological Measurement·Samjin ChoiJoo-Ho Chung
May 6, 2017·Briefings in Bioinformatics·Zhen ShengZhiwei Cao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.