PMID: 11915854Mar 28, 2002Paper

Comparison of Alora estradiol matrix transdermal delivery system with oral conjugated equine estrogen therapy in relieving menopausal symptoms. Alora Study Group

Climacteric : the Journal of the International Menopause Society
W R GoodJ E Higgins

Abstract

To compare the efficacy of two strengths of an estradiol matrix transdermal delivery system with daily oral doses of conjugated equine estrogens in reducing the frequency of moderate-to-severe hot flushes in postmenopausal women. The design of the study provided for the following treatment regimens: an estradiol transdermal delivery system (Alora 0.05 or 0.1 mg/day) administered twice weekly or oral doses of conjugated equine estrogens (CEE 0.625 or 1.25 mg) administered daily were given to 321 highly symptomatic postmenopausal women for 12 weeks following a randomized, parallel-group, double-blind, double-dummy design. Results indicate no statistically significant differences at any time point in mean frequency or mean percentage reduction in frequency of moderate-to-severe hot flushes between patients given Alora 0.1 mg/day and those receiving CEE 1.25 mg/day. Similarly, no significant differences were observed at any time in mean frequency of moderate-to-severe hot flushes between the Alora 0.05 mg/day and CEE 0.625 mg/day groups, although the group receiving CEE 0.625 mg/day exhibited a statistically greater percentage reduction than the Alora 0.05 mg/day group at weeks 3, 4 and 8. By week 12, these two treatments were stat...Continue Reading

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Citations

Sep 10, 2002·Menopause : the Journal of the North American Menopause Society·Morris NotelovitzWilliam R Good
Oct 2, 2004·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists Women's Health Care Physicians
Oct 1, 2009·Journal of Women's Health·Catherine Lynch
Mar 6, 2013·Endocrine Reviews·Franck Mauvais-JarvisAndrea L Hevener
Dec 9, 2008·Climacteric : the Journal of the International Menopause Society·M Andrikoula, G Prelevic
May 1, 2004·American Journal of Obstetrics and Gynecology·Michelle P Warren
Aug 2, 2016·The Cochrane Database of Systematic Reviews·Ana Marcia I S GaudardMaria R Torloni
Oct 18, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·S IliodromitiM Hickey

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