Comparison of ambulatory blood pressure-lowering effects of higher doses of different calcium antagonists in uncontrolled hypertension: the Calcium Antagonist Controlled-Release High-Dose Therapy in Uncontrolled Refractory Hypertensive Patients (CARILLON) Study

Blood Pressure
Hiroyuki MizunoKazuomi Kario

Abstract

Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. This was a prospective, randomized, multicenter, open-label trial. Fifty-one uncontrolled hypertensives medicated by two or more antihypertensive drugs including a renin-angiotensin system inhibitor and a calcium antagonist were randomly assigned to either the nifedipine CR (80 mg)/candesartan (8 mg) group or the amlodipine (10 mg)/candesartan (8 mg) group. The changes in 24-hr BP were comparable between the groups. The nifedipine group demonstrated a significant decrease in their urinary albumin creatinine ratio, whereas the amlodipine group demonstrated a significant decrease in their NTproBNP level. However, there was no significant difference in any biomarkers between the two groups. Nifedipine showed an almost equal effect on ambulatory blood pressure as amlodipine. Their potentially differential effects on renal protection and NTproBNP should be tested in larger samples.

References

Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ikuo SaitoUNKNOWN ADVANCE-Combi Study Group
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideyuki UnoKazuomi Kario
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsuyoshi HorikawaUNKNOWN J-HOME Study Group
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Peter W F WilsonChristopher J O'Donnell
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Alastair John Stewart Webb, Peter Malcolm Rothwell
Oct 5, 2011·Clinical and Experimental Hypertension : CHE·Naohiko Kobayashi, Toshihiko Ishimitsu
Nov 25, 2011·International Journal of Cardiology·Tadashi KonoshitaUNKNOWN Genomic Disease Outcome Consortium (G-DOC) Study Investigators
Mar 9, 2013·Stroke; a Journal of Cerebral Circulation·Aaron R FolsomChristie M Ballantyne
Apr 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoUNKNOWN Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Apr 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoMariko Kajikawa
Sep 2, 2015·Diabetes & Metabolism·C KoulisK A Jandeleit-Dahm
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius

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