Abstract
Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. This was a prospective, randomized, multicenter, open-label trial. Fifty-one uncontrolled hypertensives medicated by two or more antihypertensive drugs including a renin-angiotensin system inhibitor and a calcium antagonist were randomly assigned to either the nifedipine CR (80 mg)/candesartan (8 mg) group or the amlodipine (10 mg)/candesartan (8 mg) group. The changes in 24-hr BP were comparable between the groups. The nifedipine group demonstrated a significant decrease in their urinary albumin creatinine ratio, whereas the amlodipine group demonstrated a significant decrease in their NTproBNP level. However, there was no significant difference in any biomarkers between the two groups. Nifedipine showed an almost equal effect on ambulatory blood pressure as amlodipine. Their potentially differential effects on renal protection and NTproBNP should be tested in larger samples.
References
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Jan 22, 2005·Journal of Hypertension·Naoyuki HasebeUNKNOWN NICE Combi Study Group
Aug 2, 2005·American Journal of Hypertension·Joji IshikawaUNKNOWN J-MORE Study Group
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ikuo SaitoUNKNOWN ADVANCE-Combi Study Group
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideyuki UnoKazuomi Kario
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsuyoshi HorikawaUNKNOWN J-HOME Study Group
May 23, 2009·Biochemical and Biophysical Research Communications·Takanori MatsuiSeiya Okuda
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Peter W F WilsonChristopher J O'Donnell
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Jun 28, 2011·Clinical and Experimental Hypertension : CHE·Keisuke KugaKuniaki Ohtsuka
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Alastair John Stewart Webb, Peter Malcolm Rothwell
Oct 5, 2011·Clinical and Experimental Hypertension : CHE·Naohiko Kobayashi, Toshihiko Ishimitsu
Nov 8, 2011·Journal of the American Society of Hypertension : JASH·Motoki FukutomiKazuomi Kario
Nov 25, 2011·International Journal of Cardiology·Tadashi KonoshitaUNKNOWN Genomic Disease Outcome Consortium (G-DOC) Study Investigators
Mar 9, 2013·Stroke; a Journal of Cerebral Circulation·Aaron R FolsomChristie M Ballantyne
Jul 3, 2013·Journal of Hypertension·Giuseppe ManciaUNKNOWN Task Force Members
Aug 16, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoYusuke Ohya
Apr 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoUNKNOWN Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Apr 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoMariko Kajikawa
Sep 2, 2015·Diabetes & Metabolism·C KoulisK A Jandeleit-Dahm
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Citations
Feb 17, 2018·The Journal of Clinical Hypertension·Kazuomi KarioJi-Guang Wang
Mar 22, 2019·Clinical and Experimental Hypertension : CHE·Derya DemirtasMevlut Koc
Sep 29, 2020·Journal of Forensic Sciences·Laura Watt, Edward Sisco
Nov 3, 2020·Blood Pressure·Ying WangJi-Guang Wang
May 9, 2021·Journal of Human Hypertension·Kazuomi KarioHiromi Rakugi
Aug 1, 2021·Advances in Therapy·Rong LvWenbin Song