PMID: 9529105Apr 7, 1998Paper

Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization

Infection and Immunity
G HajishengallisS M Michalek

Abstract

Previous studies have identified an N-terminal saliva-binding region (SBR) on Streptococcus mutans surface antigen I/II (AgI/II) and suggested its importance in the initial adherence of S. mutans to saliva-coated tooth surfaces and subsequent development of dental caries. In this study, we compared the SBR with a C-terminal structural region of AgI/II (AgII) in their abilities to induce protective immunity against caries in rats. When SBR, AgII, or the whole AgI/II molecule was administered intranasally as a conjugate with the B subunit of cholera toxin (CT), in the presence of CT adjuvant, substantial levels of salivary immunoglobulin A anti-AgI/II antibodies were induced. Evaluation of caries activity showed that the SBR, though not as protective as the parent molecule, was superior to AgII and thus can be further considered as a component in a multivalent caries vaccine.

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·A S BleiweisL J Brady
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S M Michalek, N K Childers
Feb 1, 1993·Infection and Immunity·M T Dertzbaugh, C O Elson

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Citations

May 26, 1999·Emerging Infectious Diseases·T M WizemannS Langermann
Aug 15, 2002·British Medical Bulletin·Pascal Mettens, Philippe Monteyne
Mar 1, 2008·Proteomics. Clinical Applications·Jason N ColeMark J Walker
Oct 27, 2011·Journal of Dental Research·W ShiH M Yan
Aug 17, 2012·Journal of Dental Research·Y SunH M Yan
Mar 17, 2010·Expert Opinion on Therapeutic Patents·Fu Chen, Dong Wang
Jul 9, 2016·Human Vaccines & Immunotherapeutics·Ying SunHuimin Yan
May 31, 2007·FEMS Immunology and Medical Microbiology·William P McArthurL Jeannine Brady
Sep 7, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S M MichalekN K Childers
Apr 16, 1999·Oral Microbiology and Immunology·G Hajishengallis, S M Michalek
Aug 22, 2003·Oral Microbiology and Immunology·F LiN K Childers
May 27, 2006·Nature Reviews. Immunology·Martin A Taubman, David A Nash
Apr 18, 2015·Journal of Dental Research·R BaoH M Yan
May 19, 2001·Oral Microbiology and Immunology·T HarrodM W Russell
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D J Smith
Sep 14, 2019·Letters in Applied Microbiology·M Patel
Apr 26, 2002·Vaccine·Toshihiko KogaYoshio Nakano
May 4, 1999·Clinical and Diagnostic Laboratory Immunology·M FontanaR L Gregory
Oct 1, 2021·International Journal of Oral Science·Qiong ZhangJing Zou
Dec 22, 1999·The Journal of the American Dental Association·H C Slavkin

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