Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men

British Journal of Cancer
Simon PernotLaurence Weiss

Abstract

There is no consensus on screening strategy of high-grade intraepithelial neoplasia (HGAIN). Guidelines range from clinical examination with digital anorectal examination followed by standard anoscopy (SA), to anal cytology (Pap)+/- HPV genotyping. We compared screening strategy yields based on Pap, SA, and HPV-16 genotyping alone or in combination in HIV-MSM. Pap, SA, and HPV-16 genotyping were performed in all HIV-MSM attending a first anal cancer screening consultation in Paris, France. High-resolution anoscopy, the gold standard to detect HGAIN, was performed in the case of HPV-16 positivity or abnormal cytology. Yield was defined as the number of patients with HGAIN relative to the total number of patients screened. On 212 patients, the complete strategy (SA + Pap + HPV genotyping) yield (12.7%) was significantly higher than that of SA (3.3%, p < 0.001) and HPV-16 alone (6.6%, p < 0.05). Although none of the other strategies were significantly different from the complete strategy, Pap + HPV-16 and Pap + SA had closer yields (about 11%), with OR = 0.83 (95% CI [0.44;1.57]) and 0.87 (95% CI [0.46;1.64]), respectively. Pap combined with HPV-16 genotyping or SA tended towards higher yields compared to Pap alone, and closer to ...Continue Reading

References

Apr 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J M PalefskyT M Darragh
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth Y ChiaoHashem El Serag
Oct 18, 2008·Gastroentérologie Clinique Et Biologique·I Etienney, P Bauer
Dec 31, 2008·International Journal of Cancer. Journal International Du Cancer·Hugo De VuystSilvia Franceschi
Feb 4, 2009·International Journal of Cancer. Journal International Du Cancer·Brooke E HootsJennifer S Smith
Feb 27, 2010·The British Journal of Dermatology·A KreuterUNKNOWN German Competence Network HIV/AIDS
Jul 16, 2010·Diseases of the Colon and Rectum·Stephen E Goldstone, Erin Moshier
Oct 12, 2010·Revue D'épidémiologie Et De Santé Publique·L Kabamba MulongoM Dramaix Wilmet
Oct 20, 2012·AIDS·Christophe PikettyUNKNOWN Valparaiso Study Group
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe PikettySophie Grabar
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Teresa M DarraghUNKNOWN Members of the LAST Project Work Groups
Apr 24, 2013·Journal of Lower Genital Tract Disease·Martin SteinauMona Saraiya
Aug 13, 2013·International Journal of Cancer. Journal International Du Cancer·J Michael BerryJoel M Palefsky
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith A Aberg Infectious Diseases Society of America
Dec 17, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Richard J Medford, Irving E Salit
Feb 3, 2016·AIDS·Alice M SchofieldHenry C Kitchener
Feb 21, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L AbramowitzX Duval
Aug 26, 2016·Journal of Lower Genital Tract Disease·Richard John HillmanNaomi Jay
Dec 23, 2016·International Journal of Cancer. Journal International Du Cancer·Nicolas WentzensenSilvia Franceschi

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Citations

Mar 19, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A TodorovaC Traidl-Hoffmann
Jul 10, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Alexis VanhaesebrouckSophie Grabar
Sep 14, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Johanna MoreauAstrid Lievre
Jan 19, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Belen Lopez-CavanillasJose L Bartha
Mar 26, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David VeyerHélène Péré

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Methods Mentioned

BETA
genotyping
biopsy
PCR
biopsies

Clinical Trials Mentioned

NCT02135419

Software Mentioned

DARE

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