Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins

Analytical and Bioanalytical Chemistry
A R HumpageS M Froscio

Abstract

The paralytic shellfish poisoning toxins (PSTs) were, as their name suggests, discovered as a result of human poisoning after consumption of contaminated shellfish. More recently, however, the same toxins have been found to be produced by freshwater cyanobacteria. These organisms have worldwide distribution and are common in our sources of drinking water, thus presenting another route of potential human exposure. However, the regulatory limits for PSTs in drinking water are considerably lower than in shellfish. This has increased the need to find alternatives to the mouse bioassay, which, apart from being ethically questionable, does not have a limit of detection capable of detecting the PSTs in water at the regulated concentrations. Additionally, the number of naturally occurring PSTs has grown substantially since saxitoxin was first characterised, markedly increasing the analytical challenge of this group of compounds. This paper summarises the development of chromatographic, toxicity, and molecular sensor binding methodologies for detection of the PSTs in shellfish, cyanobacteria, and water contaminated by these toxins. It then summarises the advantages and disadvantages of their use for particular applications. Finally it r...Continue Reading

References

Jan 1, 1978·Journal of Agricultural and Food Chemistry·H A BatesH Rapoport
Dec 1, 1975·Australian Veterinary Journal·E J McBarronK H Walker
Aug 18, 1976·Journal of the American Chemical Society·Y ShimizuV P Miura IGullo
Mar 1, 1975·Journal of Agricultural and Food Chemistry·H A Bates, H Rapoport
Mar 5, 1975·Journal of the American Chemical Society·E J SchantzJ Clardy
Oct 15, 1975·Journal of the American Chemical Society·J BordnerH Rapoport
Sep 16, 1975·Biochemical and Biophysical Research Communications·Y ShimizuW E Fallon
Feb 9, 1976·Biochemical and Biophysical Research Communications·V E GhazarossianF M Strong
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·Y OshimaS Blackburn
Dec 29, 1971·Journal of the American Chemical Society·J L WongH Rapoport
May 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·A P Negri, G J Jones
May 15, 1993·Analytical Biochemistry·M R VieytesL M Botana
May 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·G J DoucetteF M Van Dolah
Aug 1, 1997·Applied and Environmental Microbiology·W W CarmichaelE Moczydlowski
Jul 22, 1999·Toxicon : Official Journal of the International Society on Toxinology·N LagosY Oshima
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·P PereiraY Oshima
Sep 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·L E Llewellyn, J Doyle
Oct 12, 2000·Toxicon : Official Journal of the International Society on Toxinology·P Vale, M A de M Sampayo
Feb 24, 2001·Journal of Chromatography. a·A Gago-MartínezJ F Lawrence
Oct 9, 2002·Toxicon : Official Journal of the International Society on Toxinology·L E LlewellynA P Negri
Feb 1, 2003·Trends in Cell Biology·Pao-Tien Chuang, Andrew P McMahon
Apr 22, 2003·Chemical Research in Toxicology·Maria Carmen LouzaoLuis Miguel Botana
Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Marie-Yasmine Bottein Dechraoui, John S Ramsdell
Feb 19, 2004·Journal of Chromatography. a·Carmela Dell'AversanoMichael A Quilliam
Mar 24, 2004·Toxicon : Official Journal of the International Society on Toxinology·Lyndon LlewellynMichael Quilliam
May 4, 2004·Trends in Pharmacological Sciences·Jian XuAlbrecht Wendel
Jul 1, 2004·Toxicon : Official Journal of the International Society on Toxinology·Gires UsupBoon-Koon Ng
Apr 5, 2005·Toxicon : Official Journal of the International Society on Toxinology·Robert E GawleyRichard M Tarkka
May 14, 2005·Environmental Toxicology·Jarkko RapalaLiisa Lepistö
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Masanao OkumuraBan-Ichi Tomita
Apr 29, 2006·Environmental Toxicology·Yongmei LiuLirong Song
May 18, 2006·Alternatives to Laboratory Animals : ATLA·Philipp HessUNKNOWN ECVAM/DG SANCO Workshop

❮ Previous
Next ❯

Citations

Jul 21, 2011·Analytical and Bioanalytical Chemistry·Rudolf KrskaDon Forsyth
May 1, 2012·Analytical and Bioanalytical Chemistry·Laura AnfossiGianfranco Giraudi
Apr 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Rui ZhangYuntao Zhao
Jul 22, 2014·Toxins·Mari VasamaCarolyn A Haskard
Feb 23, 2011·Ecotoxicology and Environmental Safety·François PerreaultWilliam Gerson Matias
Oct 6, 2015·Journal of Toxicology and Environmental Health. Part a·Silvia P MelegariWilliam G Matias
Mar 24, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ambbar Aballay-GonzalezAllisson Astuya
Apr 29, 2015·Toxicon : Official Journal of the International Society on Toxinology·Andrew D TurnerMyriam Algoet
Dec 31, 2011·Toxicon : Official Journal of the International Society on Toxinology·Andrew E FidlerMatthew D Krasowski
Aug 14, 2012·Biotechnology Advances·J Gallardo-RodríguezE Molina-Grima
Aug 28, 2012·Toxicon : Official Journal of the International Society on Toxinology·Andrew D TurnerWendy A Higman
Jul 31, 2013·Environment International·Sylvain MerelOlivier Thomas
Jan 5, 2011·Toxicon : Official Journal of the International Society on Toxinology·Stacey L DeGrasseAndrew Turner
Jan 13, 2011·Toxicon : Official Journal of the International Society on Toxinology·Francine M J SmithSally Gaw
Feb 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Andrew D TurnerRobert G Hatfield
Oct 4, 2011·Toxicon : Official Journal of the International Society on Toxinology·Suzanne FroscioAndrew Humpage
Jan 1, 2015·Toxicon : Official Journal of the International Society on Toxinology·Ingrid Richter, Andrew E Fidler
Oct 8, 2016·Environmental Toxicology and Pharmacology·Katie O'NeillAndrew Humpage
Oct 27, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roy W A PeakeMark D Kellogg
May 13, 2017·Toxicon : Official Journal of the International Society on Toxinology·Rebekah E WhartonRudolph C Johnson
Jan 1, 2013·Metabolites·Doreen SchwarzMartin Hagemann
Oct 5, 2017·Journal of Analytical Toxicology·P EangoorJ S Knaack
Oct 23, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ambbar Aballay-GonzálezAllisson Astuya
Sep 9, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Marcia BoderoArjen Gerssen
May 28, 2020·Toxins·Mariana I C RaposoAlisa Rudnitskaya
Aug 14, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hongbo LiPing Wang
Jul 5, 2019·The Analyst·Padmanabhan EangoorJennifer Sporty Knaack
Oct 7, 2020·Marine Drugs·Roberto Navarro QuirozElkin Navarro Quiroz
May 28, 2021·Radiation Physics and Chemistry·Alexandra M FolcikSuresh D Pillai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.