Comparison of anesthetic effects of epidural and intravenous administration of buprenorphine during operation

Journal of Anesthesia
E Yonemura, K Fukushima

Abstract

Thirty six patients were received epidural anesthesia with or without buprenorphine (BPN) during upper abdominal surgery. They were divided into three groups of 12 patients as follows; G-I received 20 ml of 1% lidocaine epidurally, G-II received 20 ml of 1% lidocaine epidurally and 0.6 mg BPN intravenously, G-III received 20 ml of 1% lidocaine with 0.6 mg BPN epidurally. Additional 5 ml of 1% lidocaine was given to any patient if systolic blood pressure or heart rate increased 10% compared to control value. Trachea was intubated following anesthetic induction with thiopental. The lungs were ventilated with a mixture of N(2)O/O(2) (33%) and pancuronium was used for muscle relaxation. The total required doses of lidocaine in G-II and G-III were decreased 60% compared to control group (G-I) ( P < 0.05). The mean period of time until the first administration of pentazocine for postoperative pain was 13 +/- 10 hr (mean +/- SD) in G-II and 19 +/- 24 hr in G-III compared to 5 +/- 4 hr in G-I ( P < 0.001). The dose of the administration of pentazocine that was required for pain relief during the first 48 postoperative hr in G-III was 54 +/- 10 mg (mean +/- SD) compared to 150 +/- 21 mg in G-I ( P < 0.02) and 106 +/- 28 mg in G-II ( P <...Continue Reading

References

Feb 1, 1985·British Journal of Anaesthesia·R A Boas, J W Villiger
Mar 1, 1985·British Journal of Anaesthesia·F S RucciP Migliori
Jun 1, 1983·Anaesthesia·A L Forrest
Oct 1, 1983·Anaesthesia·M H FaroquiJ Curran
Feb 1, 1983·Anaesthesia·D P Papworth
Apr 1, 1982·British Journal of Anaesthesia·D M JustinsF Reynolds
Jun 1, 1982·Anesthesiology·P R BromageC H Nielsen
Nov 1, 1981·Anesthesia and Analgesia·L A ShapiroR Kaplan
Nov 1, 1980·Clinical Pharmacology and Therapeutics·R E BullinghamM R Bennett

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