Comparison of anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis

Journal of Endodontics
Krishna Prasad ShettyAlexander M Luke

Abstract

The purpose of this prospective, randomized, double-blind, placebo-controlled study was to compare the anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve (IAN) blocks in patients with symptomatic irreversible pulpitis. One hundred patients with symptomatic irreversible pulpitis of mandibular posterior teeth were selected for the study. The patients received 1 mL magnesium sulfate USP 50% or distilled water (placebo) 1 hour before administration of conventional IAN block. Endodontic access cavity preparation was initiated 15 minutes after the IAN block injection. Lip numbness was recorded for all the patients. Success of IAN block was defined as no or mild pain on the visual analogue scale during access cavity preparation and initial instrumentation. The success rate for the IAN block was 58% for magnesium sulfate group and 32% for the placebo group, with statistically significant difference between the 2 groups (P = .016). In mandibular posterior teeth diagnosed with symptomatic irreversible pulpitis, preoperative administration of 1 mL magnesium sulfate USP 50% resulted in statistically significant increase in success of IAN block compared with placebo.

Citations

Jan 23, 2020·Revista do Colégio Brasileiro de Cirurgiões·Olimpio Barbosa da Silva NetoDemetrius Lucena Sampaio
Jan 24, 2020·International Journal of Dermatology·Vishal ThakurEckart Haneke
Jan 17, 2020·Journal of Dental Anesthesia and Pain Medicine·Gowri SivaramakrishnanKannan Sridharan
Jan 23, 2016·Journal of Neurophysiology·Dominik A EttlinMichael L Meier

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