Comparison of anti-viral activity of rhesus monkey and cynomolgus monkey TRIM5alphas against human immunodeficiency virus type 2 infection

Virology
Ken KonoEmi E Nakayama

Abstract

Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their ability to grow in Old World monkey (OWM) cells. We previously evaluated several HIV-2 isolates for their sensitivity to cynomolgus monkey (CM) TRIM5alpha, an anti-HIV factor in OWM cells, and found that viruses carrying proline at the 120th position of the capsid protein were sensitive to CM TRIM5alpha, whereas those with either alanine or glutamine were resistant. In the study presented here, we tested these HIV-2 isolates for their sensitivity to rhesus monkey (Rh) TRIM5alpha and found that both CM TRIM5alpha-sensitive and -resistant viruses were restricted by Rh TRIM5alpha. The variable region 1 of the SPRY domain of Rh TRIM5alpha appeared to be the determinant of this difference. Furthermore, a mutagenesis study showed that three amino acid residues TFP at the 339th to 341st positions of Rh TRIM5alpha are important for restricting HIV-2 strains resistant to CM TRIM5alpha.

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Citations

Feb 25, 2009·Immunogenetics·Welkin E Johnson, Sara L Sawyer
Dec 13, 2012·Immunogenetics·Chang-Qing YuJian-Hua Zhou
Jun 19, 2013·American Journal of Primatology·Guiqing ZhangXiaoning Wang
Jan 6, 2010·Reviews in Medical Virology·Emi E Nakayama, Tatsuo Shioda
Sep 16, 2015·AIDS·Emi E Nakayama, Tatsuo Shioda
Dec 8, 2017·Frontiers in Immunology·Daryl Anne Victoria WeatherleySarah L Rowland-Jones
Jan 13, 2018·AIDS Research and Human Retroviruses·Emi E NakayamaSiriphan Saeng-Aroon
Jun 25, 2020·Molecular Therapy. Methods & Clinical Development·Akiko IshiiShin'ichi Takeda

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