Comparison of antianginal efficacies and exercise hemodynamic effects of nifedipine and diltiazem in stable angina pectoris

The American Journal of Cardiology
W A WallaceC S Liang

Abstract

The antianginal efficacies of nifedipine (40 to 120 mg/day) and diltiazem (120 to 360 mg/day) were studied in 21 normotensive patients with chronic stable angina pectoris, using a randomized, double-blind, crossover design. Patients received each agent titrated to maximum tolerated doses for 6 weeks, after a 2-week placebo baseline period. The maximum tolerated dose for nifedipine was 72 +/- 8 (standard error) mg/day and for diltiazem 297 +/- 20 mg/day. Two patients discontinued nifedipine early because of side effects. Duration of symptom-limited treadmill exercise was longer during the nifedipine (556 +/- 43 seconds) and diltiazem periods (546 +/- 39 seconds) compared with placebo baseline (474 +/- 41 seconds, p less than 0.02). Compared with placebo, nifedipine caused a significant increase in heart rate both at rest standing and at peak exercise. Nifedipine decreased resting systolic blood pressure but had no effect at peak exercise. In contrast, diltiazem caused a significant decrease in heart rate at rest but had no effect on blood pressure at rest or at peak exercise. Thus, nifedipine and diltiazem have differential effects on heart rate and systolic blood pressure suggesting different modes of action. However, despite t...Continue Reading

References

Oct 22, 1979·The American Journal of Cardiology·M KaltenbachG Kober
Feb 1, 1986·Journal of the American College of Cardiology·D P HumenW J Kostuk
Apr 1, 1986·The American Journal of Cardiology·A UusitaloH Wendelin
Feb 1, 1987·Journal of the American College of Cardiology·X E PridaE Scott
Jul 1, 1986·The American Journal of Cardiology·S TerrisB Pitt
Dec 6, 1985·The American Journal of Cardiology·W H FrishmanJ Strom
Nov 1, 1985·American Heart Journal·M J KernR A O'Rourke
Mar 1, 1983·The American Journal of Cardiology·L G Sherman, C S Liang

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