Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A/C polysaccharide vaccine and vaccine-naïve controls

Vaccine
Ray BorrowE B Kaczmarski

Abstract

Few data are available on the kinetics of meningococcal serogroup C-specific antibody production following meningococcal serogroup C conjugate (MCC) vaccination, particularly in those who have received prior meningococcal A/C polysaccharide (MACP) vaccination(s). Laboratory staff who had previously received either one dose (n = 35), two doses (n = 18) of MACP vaccine or who were naïve to previous meningococcal vaccination (n = 42) were vaccinated with MCC. Bloods were taken pre-vaccination, on the subsequent 4 days and on days 10 and 28. Serogroup C serum bactericidal antibody (SBA), and anti-serogroup C-specific IgG, IgM and IgA were measured. There were no significant differences between the groups who had received either 2 or 1 prior dose(s) of MACP, therefore, these results were combined. Up to day 4 there was no evidence of a significant increase or decrease in the median levels of SBA, IgG, IgM or IgA in either the naïve or MACP groups, although about 20% of individuals did have 4-fold SBA rises by day 4. By day 10 there were large significant increases in the levels of SBA, IgG, IgM and IgA with respective fold increases from pre-vaccination levels of 4.6, 1.9, 1.2 and 2.1 in the MACP group and 270, 13.4, 4.8 and 33.8 in...Continue Reading

References

Dec 1, 1975·The Journal of Clinical Investigation·R GoldE C Gotschlich
Sep 1, 1988·The Journal of Infection·R G MastertonD M Jones
Sep 5, 1998·The Journal of Infectious Diseases·D M GranoffE L Anderson
Dec 1, 1998·JAMA : the Journal of the American Medical Association·N E MacDonaldD M Granoff
Sep 24, 1999·Current Medical Research and Opinion·D V MadoreD H Smith
Apr 19, 2000·JAMA : the Journal of the American Medical Association·N E MacDonaldD M Granoff

❮ Previous
Next ❯

Citations

Aug 30, 2002·Seminars in Pediatric Infectious Diseases·M Soriano-GabarróNancy E Rosenstein
May 17, 2002·Current Opinion in Infectious Diseases·Paul Balmer, Elizabeth Miller
Sep 13, 2007·The Pediatric Infectious Disease Journal·Dan M Granoff, Andrew J Pollard
Jan 19, 2006·Clinical Microbiology Reviews·Lee H Harrison
Dec 23, 2003·Infection and Immunity·Paul BalmerRaymond Borrow
Apr 30, 2003·Archives of Disease in Childhood·J McVernonE R Moxon
Sep 2, 2004·Paediatric Drugs·Jens U Rüggeberg, Andrew J Pollard
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Dec 14, 2011·The Journal of Infectious Diseases·Siggeir F BrynjolfssonIngileif Jonsdottir
Nov 13, 2015·Expert Review of Vaccines·Al-Mamoon BadahdahAmeneh Khatami
Oct 16, 2004·Expert Review of Vaccines·Janet SukerBarbara Bolgiano
Mar 3, 2009·Expert Review of Vaccines·Ray Borrow, Jamie Findlow
Jan 5, 2002·Expert Opinion on Biological Therapy·Raman Lakshman, Adam Finn
Jun 19, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ghassan DbaiboJacqueline M Miller
Sep 2, 2004·British Medical Bulletin·Adam Finn
Feb 16, 2007·Clinical and Vaccine Immunology : CVI·Gunnstein NorheimEinar Rosenqvist
Sep 6, 2012·Tropical Medicine & International Health : TM & IH·Ray Borrow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.