Comparison of antifungal efficacies of moxifloxacin, liposomal amphotericin B, and combination treatment in experimental Candida albicans endophthalmitis in rabbits

Canadian Journal of Microbiology
Yudum Tiftikcioğlu DerenBerati Hasanreisoglu

Abstract

The goal of this study was to compare in vitro and in vivo efficacy of moxifloxacin and liposomal amphotericin B (Amp-B) monotherapies and combination treatment against Candida albicans in an exogenous endophthalmitis model in rabbit eyes. Microplate dilution tests and checkerboard analysis were performed to detect in vitro efficacies. Endophthalmitis was induced by intravitreal injection of C. albicans in 40 rabbit eyes with simultaneous intravitreal drug injection according to prophylactic treatment groups. Group 1 (control group) received 0.1 mL of balanced salt solution, group 2 (moxi group) 100 microg moxifloxacin/0.1 mL, group 3 (Amp-B group) 10 microg liposomal Amp-B/0.1 mL, and group 4 (combi group) both 100 microg moxifloxacin/0.1 mL [DOSAGE ERROR CORRECTED] and 10 microg liposomal Amp-B/0.05 mL intravitreally. Clinical examination, quantitative analysis of microorganisms, and histopathologic examination were performed as in vivo studies. The minimum inhibitory concentration of liposomal Amp-B against C. albicans was found to be 1 microg/mL. Moxifloxacin showed no inhibition of in vitro C. albicans growth. The minimum inhibitory concentration values of liposomal Amp-B for C. albicans were reduced two- to eightfold with...Continue Reading

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Citations

Oct 16, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mo Sae KimChul Young Choi
Dec 17, 2010·Current Eye Research·Ayse Kalkanci, Sengul Ozdek
Jul 11, 2016·Revista iberoamericana de micología·José Luis Del Pozo, Emilia Cantón
Dec 18, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Dalhoff
Feb 23, 2013·Journal of Industrial Microbiology & Biotechnology·Lihua HouHaiyong Wang
Mar 18, 2017·Cornea·Alice Y MatobaAnna E Lehmann
Sep 18, 2020·Investigative Ophthalmology & Visual Science·Bruce G RottmannAshok Kumar
Nov 10, 2012·The International Journal of Artificial Organs·Melania IñigoJose L Del Pozo
Apr 15, 2017·World Journal of Microbiology & Biotechnology·Ashwini JadhavSankunny Mohan Karuppayil
Apr 20, 2021·In Silico Pharmacology·Ashwini Khanderao Jadhav, Sankunny Mohan Karuppayil
Jun 22, 2021·Applied Microbiology and Biotechnology·Qian ZhangZhangyong Song

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