Jul 3, 1976

Comparison of antihypertensive activity of beta-blocking drugs during chronic treatment

British Medical Journal
C DavidsonS H Taylor

Abstract

The hypotensive activity of five beta-adrenoceptor antagonists with different ancillary pharmacological properties was compared in a randomised double-blind factorial trial in 25 untreated patients with stable, uncomplicated essential hypertension. In doses that produced similar reductions in exercise tachycardia all drugs had similar blood-pressure lowering activity, greater on systolic than diastolic pressure and greatest during exercise. With the exception of vasodilator activity the possession of any particular combinaton of ancillary pharmacological properties did not significantly influence the specific antihypertensive activity of these compounds.

Mentioned in this Paper

Diastolic Blood Pressure
Essential Hypertension
Propanolamines
Hypertensive Disease
Clinical Trials
Trasicor
Rexigen
Dose-Response Relationship, Drug
Dalzic
Placebos

About this Paper

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