Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation

Anat GalorJennifer E Thorne


To compare the relative effectiveness and side effect profiles of antimetabolite drugs in the treatment of noninfectious ocular inflammation. Retrospective cohort study. A total of 257 patients with inflammatory eye disease seen in a single-center, academic practice and treated with an antimetabolite as a first-line immunosuppressive agent from 1984 to 2006. Data recorded included demographics, antimetabolite and prednisone doses, use of other immunosuppressive drugs, response to therapy, and side effects associated with drug use. Ability to control ocular inflammation and to taper prednisone to <or=10 mg daily ("treatment success"); incidence of treatment-related side effects. Ninety patients with inflammatory eye disease were treated with methotrexate, 38 patients were treated with azathioprine, and 129 patients were treated with mycophenolate. Uveitis accounted for the majority of the diagnoses (67%, 66%, and 68% for methotrexate, azathioprine, and mycophenolate, respectively), followed by scleritis (23%, 18%, 17% for methotrexate, azathioprine, and mycophenolate, respectively). The median time to treatment success was 4.0, 4.8, and 6.5 months for the mycophenolate, azathioprine, and methotrexate treatment groups, respective...Continue Reading

Associated Clinical Trials


Feb 1, 1978·Archives of Ophthalmology·R H AndraschR P Burns
May 1, 1969·The British Journal of Ophthalmology·J D MathewsI R Mackay
Nov 4, 1998·Lancet·D J KilmartinAndrew D Dick
Jan 26, 1999·Ophthalmology·S DevG J Jaffe
Dec 4, 2003·Clinical & Experimental Ophthalmology·Chun H LauSusan Lightman
Jun 21, 2005·The British Journal of Ophthalmology·A R Malik, C Pavesio
Aug 3, 2005·Ophthalmology·Jennifer E ThorneJames P Dunn
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsStandardization of Uveitis Nomenclature (SUN) Working Group
Apr 7, 2006·Ocular Immunology and Inflammation·Masoud SoheilianGholam A Peyman
Jun 14, 2006·International Ophthalmology Clinics·Eva Christina Kim, C Stephen Foster
Jul 1, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anshoo ChoudharyIan A Pearce
Jul 11, 2006·The British Journal of Ophthalmology·Deshka DoychevaManfred Zierhut


Jul 2, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Deshka DoychevaChristoph Deuter
Nov 8, 2011·Journal of Ophthalmic Inflammation and Infection·Elizabeth Esterberg, Nisha R Acharya
Mar 29, 2012·Journal of Ophthalmic Inflammation and Infection·Emmett T Cunningham
Aug 7, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ingeborg StalmansMichael V W Bergamini
Jul 9, 2011·Current Opinion in Rheumatology·C Egla Rabinovich
Nov 8, 2012·Cornea·Jennifer M NottageIrving Raber
Jun 2, 2012·Clinical Ophthalmology·Ayse Yagci
Dec 24, 2009·Indian Journal of Ophthalmology·B Manohar Babu, S R Rathinam
Dec 11, 2013·Nature Reviews. Rheumatology·Mathieu ArtifoniXavier Puéchal
Nov 22, 2014·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F MackensenT Hudde
Oct 16, 2009·Current Opinion in Ophthalmology·Maria Jancevski, C Stephen Foster
Dec 17, 2009·Ocular Immunology and Inflammation·Srilakshmi M SharmaAndrew D Dick
Dec 31, 2014·Ocular Immunology and Inflammation·Rola N HamamAhmad M Mansour
Sep 15, 2012·Ocular Immunology and Inflammation·Baoying LiuRobert B Nussenblatt
Feb 18, 2016·Pediatric Rheumatology Online Journal·Lauren A HendersonChildhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Investigators
Feb 22, 2013·Expert Opinion on Pharmacotherapy·Robert M BeardsleyPhoebe Lin
Sep 17, 2014·Expert Opinion on Pharmacotherapy·Kyungmin LeeC Stephen Foster
Apr 25, 2009·Expert Opinion on Investigational Drugs·Fiona LyonSusan Lightman
Nov 28, 2013·Expert Opinion on Emerging Drugs·Theresa G Leung, Jennifer E Thorne
Jul 12, 2012·Expert Opinion on Biological Therapy·Jangwon HeoQuan Dong Nguyen
Aug 6, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Keith WroblewskiRobert B Nussenblatt
Nov 5, 2013·Rheumatic Diseases Clinics of North America·Andreas ReiffSeza Özen
Oct 16, 2012·Ophthalmology·Anthony C GregorySystemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group
Nov 29, 2011·Survey of Ophthalmology·Khayyam DurraniC Stephen Foster
Dec 10, 2015·Drugs·Archana AirodyRichard Gale
Oct 26, 2010·La Revue de médecine interne·L VarronPascal Sève
Jul 25, 2015·The Lancet. Respiratory Medicine·Robert P Baughman, Jan C Grutters
Jan 1, 2010·American Journal of Ophthalmology·Ebenezer DanielJohn H Kempen
Mar 25, 2016·Orphanet Journal of Rare Diseases·Marcelo Mendes LavezzoJoyce Hisae Yamamoto
Jul 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Majid AbrishamiAmir Norouzpour
Nov 25, 2015·The Surgical Clinics of North America·Shaun R Brown, Lisa C Coviello
Mar 19, 2014·La Revue de médecine interne·E HéronT Bourcier
Jul 3, 2009·American Journal of Ophthalmology·Sirichai PasadhikaEric B Suhler
Sep 1, 2015·Primary Care·James P Dunn
Oct 18, 2014·Seminars in Ophthalmology·Eduardo UchiyamaLucia Sobrin
May 21, 2015·Clinical Reviews in Allergy & Immunology·Robert P Baughman, Elyse E Lower
Jan 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Ujwala BahetiC Stephen Foster
Sep 10, 2014·American Journal of Ophthalmology·Naomi R GoldbergDouglas A Jabs
Jun 19, 2016·Survey of Ophthalmology·J Daniel DiazDavid C Gritz
Jun 15, 2016·American Journal of Ophthalmology·Lydia AbásoloLuis Rodriguez-Rodriguez
Jul 28, 2016·Current Opinion in Pulmonary Medicine·Jared ChiarchiaroKevin F Gibson
Oct 19, 2016·Survey of Ophthalmology·Dana AhnoodAlastair K Denniston
Oct 21, 2016·BMC Ophthalmology·Malik Y GhannamJohn O Mason
Mar 30, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Maxwell S StemLisa J Faia
Jul 14, 2012·São Paulo Medical Journal = Revista Paulista De Medicina·Marcelo GehlenThelma Larocca Skare
Nov 22, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Deutsche Ophthalmologische Gesellschaft, Berufsverband der Augenärzte Deutschlands e. V.
Mar 20, 2019·Expert Opinion on Biological Therapy·Sara TouhamiDavid Saadoun
May 6, 2019·Drugs & Aging·Erminia RidoloC Incorvaia
Apr 14, 2018·Ocular Immunology and Inflammation·Sowkath AliJyotirmay Biswas
Nov 12, 2019·Ocular Immunology and Inflammation·Alejandro Gómez-GómezLuis Rodriguez-Rodriguez
Dec 24, 2019·Expert Review of Respiratory Medicine·Aman Pande, Daniel A Culver
May 16, 2020·Acta Ophthalmologica·Evianne L de GrootJeannette Ossewaarde-van Norel
Aug 5, 2020·Acta Ophthalmologica·Rianne Elise Van BentumIrene E van der Horst-Bruinsma
Sep 11, 2019·JAMA Ophthalmology·Douglas A Jabs
Oct 28, 2019·Seminars in Ophthalmology·Levente CzompaAdam Kemeny-Beke
Jul 2, 2018·International Ophthalmology·Mohammad Ali ShahabSidra Zafar
Jan 1, 2017·Expert Review of Ophthalmology·Jared E KnickelbeinNida H Sen
Jul 27, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Berufsverband der Augenärzte Deutschlands e. V. (BVA), Deutsche Ophthalmologische Gesellschaft (DOG)
Aug 28, 2020·Journal of Ophthalmology·Ge Wang, Xiaoyan Peng
Oct 1, 2015·Taiwan Journal of Ophthalmology·Dana M Hornbeak, Jennifer E Thorne
Sep 10, 2019·Expert Opinion on Emerging Drugs·Uwe PleyerJudith Rademacher
May 6, 2017·Current Treatment Options in Cardiovascular Medicine·Laura YoungRory Hachamovitch
Aug 23, 2020·Indian Journal of Ophthalmology·Hitesh AgrawalMudit Tyagi
Oct 28, 2020·Japanese Journal of Ophthalmology·Tomona HiyamaYoshiaki Kiuchi

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