Comparison of antimicrobial resistance genes in nontyphoidal salmonellae of serotypes enteritidis, hadar, and virchow from humans and food-producing animals in England and wales

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Katie L HopkinsE J Threlfall

Abstract

Isolates of Salmonella enterica serovars Enteritidis (n = 17), Hadar (n = 18), and Virchow (n = 13) from cases of human infection and from food production animals were screened using a miniaturized antimicrobial microarray to determine the number and spectra of resistance genes. Among Enteritidis, the number of genes detected was: animal isolates, mean = 4.6; human isolates, mean = 5.3. Resistance to streptomycin, trimethoprim, and sulfonamides was usually encoded by only one resistance gene in animal isolates, but human isolates often carried more than one gene encoding resistance to the same class of antimicrobial. Among Hadar, the number of genes detected was: animal isolates, mean = 2.0; human strains, mean = 2.6. Resistance to streptomycin was encoded by strA, rather than aadA genes because these were detected in only one human isolate. Among Virchow, the number of genes detected was: animal isolates, mean = 1.6; human isolates, mean = 5.6. As with Enteritidis, human Hadar isolates often carried more than one gene encoding resistance to the same class of antimicrobial. Due to the complexity of routes of transmission of Salmonella spp. from food production animals to humans, full phenotypic and genotypic comparison of resis...Continue Reading

References

Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Vincent Perreten, Patrick Boerlin
Jun 25, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E J ThrelfallK Speed
May 18, 2006·International Journal of Antimicrobial Agents·Geraldine DoranMartin Cormican
May 24, 2006·Microbes and Infection·Geovana Brenner MichaelStefan Schwarz
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Virve I EnnePeter M Bennett

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Citations

Aug 5, 2008·Foodborne Pathogens and Disease·Avraham Rasooly, Keith E Herold
Nov 18, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jonathan G FryePaula J Fedorka-Cray
May 28, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C ChuC-H Chiu
Dec 19, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Emma StubberfieldMuna F Anjum

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