Comparison of antioxidant and antiproliferative activity between Kunlun Chrysanthemum flowers polysaccharides (KCCP) and fraction PII separated by column chromatography

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Siqun JingLiang-Jun Yan

Abstract

The aim of the present study was to compare the antioxidant and antiproliferative effects on cancer cells between Kunlun Chrysanthemum flowers polysaccharides (KCCP) and its fraction PII that were separated by Biologic low pressure (LP) chromatography system followed by DEAE cellulose column chromatography. Results of in vitro experiments showed that the reducing power and the scavenging capacity of KCCP towards hydroxyl radicals (OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals increased in a concentration dependent manner and were stronger than that of fraction PII. Results of the antiproliferative effect of KCCP and fraction PII on cervical cancer HeLa cells, esophagus cancer Eca109 cells, and mouse ascites hepatomas H22 cells indicated that both KCCP and its fraction PII possessed inhibitory activity on all the tested cancer cells at a dose- and time-dependent manner, with KCCP showing higher inhibitory activity than that of fraction PII. The present study demonstrates that KCCP and its fraction PII have antioxidant properties that may help fight cancers.

References

Sep 15, 2009·Environmental Health Perspectives·Jessica I Lundin, Harvey Checkoway
Jul 26, 2012·International Journal of Biological Macromolecules·Xiaoqin HuangHui Wang
Oct 18, 2012·Journal of Agricultural and Food Chemistry·Erika Mellado-Mojica, Mercedes G López
Nov 10, 2012·Journal of the Science of Food and Agriculture·Siqun JingZexin Ma
Feb 16, 2013·Food Chemistry·Yali WangJianbo Xiao
Feb 11, 2014·Carbohydrate Polymers·Predeep Kumar Samal, Jawahar Singh Dangi

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Citations

Feb 3, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qian YuChunyan Yan

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